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Irinotecan

Synonyms

SourcesNames Used
CCLE, FIMMIrinotecan
gCSIirinotecan
GRAYCPT-11
PharmacoGx Irinotecan

External IDs

DatabaseIdentifier
Smiles: CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
Inchikey: UWKQSNNFCGGAFS-XIFFEERXSA-N
Pubchem: 60838

Annotated Targets

TOP1, TOP1MT

FDA Approval Status

Approved
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Top molecular features associated with response to Irinotecan


Feature TypeStandardized
Nominal ANOVA
mRNA HNRNPD CCLE pan-cancer AAC 0.29 7e-08
mRNA SRSF1 gCSI pan-cancer AAC 0.27 8e-08
mRNA HNRNPD gCSI pan-cancer AAC 0.28 9e-08
mRNA ATG4C gCSI pan-cancer AAC 0.3 1e-07
mRNA EXOSC9 CCLE pan-cancer AAC 0.29 1e-07
mRNA CEACAM16 gCSI pan-cancer AAC -0.28 1e-07
mRNA WRAP53 gCSI pan-cancer AAC 0.27 1e-07
mRNA MRPL42 CCLE pan-cancer AAC 0.28 1e-07
mRNA SRSF7 gCSI pan-cancer AAC 0.28 1e-07
mRNA PRPF38A CCLE pan-cancer AAC 0.3 1e-07
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