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Crizotinib

Synonyms

SourcesNames Used
CCLE, GRAYPF-2341066
GDSC1000, FIMMCrizotinib
gCSI, CTRPv2crizotinib
PharmacoGx Crizotinib

External IDs

DatabaseIdentifier
Smiles: CC(C1=C(C=C(C=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
Inchikey: SCJHEFQWKWHQTO-GFCCVEGCSA-N
Pubchem: 54613769

Annotated Targets

MET, ALK

FDA Approval Status

Approved
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Top molecular features associated with response to Crizotinib


Feature TypeStandardized
Nominal ANOVA
mRNA CAPZA2 CCLE pan-cancer AAC 0.28 4e-10
mRNA HGF CCLE pan-cancer AAC 0.27 7e-09
mRNA RREB1 CCLE pan-cancer AAC 0.25 5e-07
mRNA NUAK2 CCLE pan-cancer AAC -0.24 2e-06
mRNA USP32 CCLE pan-cancer AAC 0.21 3e-06
mRNA NKG7 CCLE pan-cancer AAC 0.23 4e-06
mRNA CTDP1 CCLE pan-cancer AAC 0.23 4e-06
mRNA GPR84 CCLE pan-cancer AAC 0.21 9e-06
mRNA GCSAM CCLE pan-cancer AAC -0.25 1e-05
mRNA CISH CCLE pan-cancer AAC 0.21 1e-05
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