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AZ628

Synonyms

SourcesNames Used
GDSC1000AZ628
PharmacoGx AZ628

External IDs

DatabaseIdentifier
Smiles: CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C
Inchikey: ZGBGPEDJXCYQPH-UHFFFAOYSA-N
Pubchem: 11676786

Annotated Targets

BRAF, RAF1

FDA Approval Status

Not Approved
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Top molecular features associated with response to AZ628


Feature TypeStandardized
Nominal ANOVA
mRNA TKT GDSC1000 pan-cancer AAC 0.21 3e-05
mRNA MTMR1 GDSC1000 pan-cancer AAC -0.2 3e-05
mRNA TMEM79 GDSC1000 pan-cancer AAC -0.22 3e-05
mRNA NES GDSC1000 pan-cancer AAC 0.24 3e-05
mRNA BEND4 GDSC1000 pan-cancer AAC -0.23 3e-05
mRNA MITF GDSC1000 pan-cancer AAC 0.26 3e-05
mRNA FUCA2 GDSC1000 pan-cancer AAC 0.23 3e-05
mRNA MAN2C1 GDSC1000 pan-cancer AAC 0.2 3e-05
mRNA TIFA GDSC1000 pan-cancer AAC -0.28 3e-05
mRNA PHLDA1 GDSC1000 pan-cancer AAC 0.27 3e-05
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