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Compounds
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Tipifarnib
Tipifarnib
Synonyms
Sources
Names Used
GDSC1000
,
FIMM
Tipifarnib
PharmacoGx
Tipifarnib
External IDs
Database
Identifier
Smiles:
CN1C=NC=C1C(C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N
Inchikey:
PLHJCIYEEKOWNM-HHHXNRCGSA-N
Pubchem:
159324
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with Tipifarnib
(per dataset)
0
100
200
300
400
500
600
700
800
900
# cell lines
CCLE
gCSI
GRAY
CTRPv2
UHNBreast
FIMM
GDSC1000
0
0
0
0
0
50
932
Download SVG
Number of tissues tested with Tipifarnib
(per dataset)
0
5
10
15
20
25
30
35
# tissues
CCLE
gCSI
GRAY
CTRPv2
UHNBreast
FIMM
GDSC1000
0
0
0
0
0
4
35
Download SVG
Dataset Select
all
GDSC1000
FIMM
Tipifarnib: AAC
AAC
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
0.80
0.90
H2369
H2369
QIMR-WIL
QIMR-WIL
MEL-JUSO
MEL-JUSO
SNU-398
SNU-398
WM1158
WM1158
ETK-1
ETK-1
NCI-H847
NCI-H847
786-0
786-0
Daoy
Daoy
NCI-H3122
NCI-H3122
NALM-6
NALM-6
KYSE-270
KYSE-270
LCLC-103H
LCLC-103H
IHH-4
IHH-4
Calu-1
Calu-1
NB4
NB4
IA-LM
IA-LM
VMRC-RCW
VMRC-RCW
SK-LMS-1
SK-LMS-1
KM12
KM12
SIG-M5
SIG-M5
SNG-M
SNG-M
SK-N-SH
SK-N-SH
NCI-H2286
NCI-H2286
MOLP-8
MOLP-8
CMK
CMK
MCC13
MCC13
HMV-II
HMV-II
BC-1
BC-1
NCI-H2122
NCI-H2122
NCI-H748
NCI-H748
TC-71
TC-71
SW684
SW684
A498
A498
SK-MEL-1
SK-MEL-1
CHSA0011
CHSA0011
NCI-H1573
NCI-H1573
JVM-3
JVM-3
SNU-C1
SNU-C1
OSA-80
OSA-80
NCI-H720
NCI-H720
U-87-MG
U-87-MG
NCI-H1385
NCI-H1385
JAR
JAR
EW-24
EW-24
SW780
SW780
MSTO-211H
MSTO-211H
RL
RL
EC-GI-10
EC-GI-10
NCI-H23
NCI-H23
NCI-H1155
NCI-H1155
NCI-SNU-16
NCI-SNU-16
SCH
SCH
NCI-H1522
NCI-H1522
NCI-H1838
NCI-H1838
HSC-39
HSC-39
P31-FUJ
P31-FUJ
CW-2
CW-2
NCI-H322M
NCI-H322M
TOV-21G
TOV-21G
H2369
QIMR-WIL
MEL-JUSO
SNU-398
WM1158
ETK-1
NCI-H847
786-0
Daoy
NCI-H3122
NALM-6
KYSE-270
LCLC-103H
IHH-4
Calu-1
NB4
IA-LM
VMRC-RCW
SK-LMS-1
KM12
SIG-M5
SNG-M
SK-N-SH
NCI-H2286
MOLP-8
CMK
MCC13
HMV-II
BC-1
NCI-H2122
NCI-H748
TC-71
SW684
A498
SK-MEL-1
CHSA0011
NCI-H1573
JVM-3
SNU-C1
OSA-80
NCI-H720
U-87-MG
NCI-H1385
JAR
EW-24
SW780
MSTO-211H
RL
EC-GI-10
NCI-H23
NCI-H1155
NCI-SNU-16
SCH
NCI-H1522
NCI-H1838
HSC-39
P31-FUJ
CW-2
NCI-H322M
TOV-21G
H2369: 0.95
Synonyms: H2369
QIMR-WIL: 0.87
Synonyms: QIMR-WIL
MEL-JUSO: 0.82
Synonyms: MEL-JUSO, MELJUSO
SNU-398: 0.82
Synonyms: SNU-398, SNU398
WM1158: 0.80
Synonyms: WM1158
ETK-1: 0.79
Synonyms: ETK-1
NCI-H847: 0.79
Synonyms: NCI-H847
786-0: 0.78
Synonyms: 786-0, 786-O, 786-o, 786O
Daoy: 0.77
Synonyms: Daoy, DAOY
NCI-H3122: 0.76
Synonyms: NCI-H3122
NALM-6: 0.76
Synonyms: NALM-6, NALM6
KYSE-270: 0.75
Synonyms: KYSE-270
LCLC-103H: 0.74
Synonyms: LCLC-103H, LCLC103H
IHH-4: 0.74
Synonyms: IHH-4
Calu-1: 0.73
Synonyms: Calu-1, CALU1
NB4: 0.72
Synonyms: NB4, NB-4
IA-LM: 0.72
Synonyms: IA-LM, IALM
VMRC-RCW: 0.72
Synonyms: VMRC-RCW, VMRCRCW
SK-LMS-1: 0.71
Synonyms: SK-LMS-1, SKLMS1
KM12: 0.70
Synonyms: KM12, KM-12
SIG-M5: 0.70
Synonyms: SIG-M5, SIGM5
SNG-M: 0.70
Synonyms: SNG-M, SNGM
SK-N-SH: 0.69
Synonyms: SK-N-SH, SKNSH
NCI-H2286: 0.69
Synonyms: NCI-H2286, NCIH2286
MOLP-8: 0.69
Synonyms: MOLP-8, MOLP8
CMK: 0.68
Synonyms: CMK
MCC13: 0.68
Synonyms: MCC13
HMV-II: 0.68
Synonyms: HMV-II, HMVII
BC-1: 0.68
Synonyms: BC-1
NCI-H2122: 0.67
Synonyms: NCI-H2122, NCIH2122
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
NCI-H748: 0.02
Synonyms: NCI-H748
TC-71: 0.02
Synonyms: TC-71, TC71
SW684: 0.02
Synonyms: SW684
A498: 0.02
Synonyms: A498, A-498
SK-MEL-1: 0.02
Synonyms: SK-MEL-1, SKMEL1
CHSA0011: 0.02
Synonyms: CHSA0011
NCI-H1573: 0.01
Synonyms: NCI-H1573, NCIH1573
JVM-3: 0.01
Synonyms: JVM-3, JVM3
SNU-C1: 0.01
Synonyms: SNU-C1, SNUC1
OSA-80: 0.01
Synonyms: OSA-80
NCI-H720: 0.01
Synonyms: NCI-H720
U-87-MG: 0.01
Synonyms: U-87-MG, U-87 MG, U-87_MG, U87MG
NCI-H1385: 0.01
Synonyms: NCI-H1385, NCIH1385
JAR: 0.01
Synonyms: JAR
EW-24: 0.01
Synonyms: EW-24
SW780: 0.01
Synonyms: SW780, SW 780, SW_780
MSTO-211H: 0.01
Synonyms: MSTO-211H, MSTO211H
RL: 0.01
Synonyms: RL
EC-GI-10: 0.01
Synonyms: EC-GI-10, ECGI10
NCI-H23: 0.00
Synonyms: NCI-H23, NCIH23
NCI-H1155: 0.00
Synonyms: NCI-H1155, NCIH1155
NCI-SNU-16: 0.00
Synonyms: NCI-SNU-16, SNU-16
SCH: 0.00
Synonyms: SCH
NCI-H1522: 0.00
Synonyms: NCI-H1522
NCI-H1838: 0.00
Synonyms: NCI-H1838, NCIH1838
HSC-39: 0.00
Synonyms: HSC-39
P31-FUJ: 0.00
Synonyms: P31-FUJ, P31/FUJ, P31_FUJ, P31FUJ
CW-2: 0.00
Synonyms: CW-2, CW2
NCI-H322M: 0.00
Synonyms: NCI-H322M
TOV-21G: 0.00
Synonyms: TOV-21G, TOV21G
Download SVG
-4.00
-2.00
0.00
2.00
4.00
6.00
8.00
10.00
12.00
LN-405
LN-405
TT
TT
PCI-38
PCI-38
MKL-1-subclone-2
MKL-1-subclone-2
MDA-MB-134-VI
MDA-MB-134-VI
HDLM-2
HDLM-2
ARH-77
ARH-77
OPM-2
OPM-2
NCI-H838
NCI-H838
NCI-H510A
NCI-H510A
TE 441.T
TE 441.T
CL-11
CL-11
KMRC-1
KMRC-1
NCI-H1618
NCI-H1618
RCM-1
RCM-1
NB1
NB1
LB647-SCLC
LB647-SCLC
BE2-M17
BE2-M17
DMS-153
DMS-153
LOUCY
LOUCY
MS-1
MS-1
LU-134-A
LU-134-A
NCI-H1703
NCI-H1703
DMS-79
DMS-79
NB5
NB5
SCLC-21H
SCLC-21H
KARPAS-299
KARPAS-299
K5
K5
NCI-H196
NCI-H196
LU-165
LU-165
SK-N-SH
SK-N-SH
CMK
CMK
KU812
KU812
BC-1
BC-1
HMV-II
HMV-II
THP-1
THP-1
WM1158
WM1158
KON
KON
786-0
786-0
VMRC-RCW
VMRC-RCW
KASUMI-1
KASUMI-1
KM12
KM12
ML-2
ML-2
JSC-1
JSC-1
HPAC
HPAC
NB4
NB4
REH
REH
NCI-H3122
NCI-H3122
A4-Fuk
A4-Fuk
NALM-6
NALM-6
IA-LM
IA-LM
IHH-4
IHH-4
MOLP-8
MOLP-8
SIG-M5
SIG-M5
Daoy
Daoy
SNU-398
SNU-398
QIMR-WIL
QIMR-WIL
MEL-JUSO
MEL-JUSO
NCI-H847
NCI-H847
RPMI-6666
RPMI-6666
LN-405
TT
PCI-38
MKL-1-subclone-2
MDA-MB-134-VI
HDLM-2
ARH-77
OPM-2
NCI-H838
NCI-H510A
TE 441.T
CL-11
KMRC-1
NCI-H1618
RCM-1
NB1
LB647-SCLC
BE2-M17
DMS-153
LOUCY
MS-1
LU-134-A
NCI-H1703
DMS-79
NB5
SCLC-21H
KARPAS-299
K5
NCI-H196
LU-165
SK-N-SH
CMK
KU812
BC-1
HMV-II
THP-1
WM1158
KON
786-0
VMRC-RCW
KASUMI-1
KM12
ML-2
JSC-1
HPAC
NB4
REH
NCI-H3122
A4-Fuk
NALM-6
IA-LM
IHH-4
MOLP-8
SIG-M5
Daoy
SNU-398
QIMR-WIL
MEL-JUSO
NCI-H847
RPMI-6666
LN-405: 12.84 (log10 µM)
Synonyms: LN-405
TT: 7.71 (log10 µM)
Synonyms: TT
PCI-38: 6.70 (log10 µM)
Synonyms: PCI-38
MKL-1-subclone-2: 6.40 (log10 µM)
Synonyms: MKL-1-subclone-2
MDA-MB-134-VI: 5.43 (log10 µM)
Synonyms: MDA-MB-134-VI, MDAMB134VI, mdamb134vi
HDLM-2: 5.23 (log10 µM)
Synonyms: HDLM-2, HDLM2
ARH-77: 5.19 (log10 µM)
Synonyms: ARH-77
OPM-2: 5.18 (log10 µM)
Synonyms: OPM-2, OPM2
NCI-H838: 5.12 (log10 µM)
Synonyms: NCI-H838, NCIH838
NCI-H510A: 4.68 (log10 µM)
Synonyms: NCI-H510A, NCI-H510, NCIH510
TE 441.T: 4.26 (log10 µM)
Synonyms: TE 441.T, TE_441.T, TE-441-T, TE441T
CL-11: 4.18 (log10 µM)
Synonyms: CL-11, CL11
KMRC-1: 4.09 (log10 µM)
Synonyms: KMRC-1, KMRC1
NCI-H1618: 3.97 (log10 µM)
Synonyms: NCI-H1618
RCM-1: 3.82 (log10 µM)
Synonyms: RCM-1, RCM1
NB1: 3.75 (log10 µM)
Synonyms: NB1, NB-1
LB647-SCLC: 3.62 (log10 µM)
Synonyms: LB647-SCLC
BE2-M17: 3.62 (log10 µM)
Synonyms: BE2-M17
DMS-153: 3.60 (log10 µM)
Synonyms: DMS-153, DMS 153, DMS_153
LOUCY: 3.55 (log10 µM)
Synonyms: LOUCY, Loucy
MS-1: 3.55 (log10 µM)
Synonyms: MS-1
LU-134-A: 3.52 (log10 µM)
Synonyms: LU-134-A
NCI-H1703: 3.51 (log10 µM)
Synonyms: NCI-H1703, NCIH1703
DMS-79: 3.44 (log10 µM)
Synonyms: DMS-79, DMS 79, DMS_79, DMS79
NB5: 3.44 (log10 µM)
Synonyms: NB5
SCLC-21H: 3.42 (log10 µM)
Synonyms: SCLC-21H, SCLC21H
KARPAS-299: 3.40 (log10 µM)
Synonyms: KARPAS-299, KARPAS299
K5: 3.27 (log10 µM)
Synonyms: K5
NCI-H196: 3.02 (log10 µM)
Synonyms: NCI-H196, NCIH196
LU-165: 3.00 (log10 µM)
Synonyms: LU-165
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
SK-N-SH: -0.80 (log10 µM)
Synonyms: SK-N-SH, SKNSH
CMK: -0.81 (log10 µM)
Synonyms: CMK
KU812: -0.82 (log10 µM)
Synonyms: KU812
BC-1: -0.85 (log10 µM)
Synonyms: BC-1
HMV-II: -0.90 (log10 µM)
Synonyms: HMV-II, HMVII
THP-1: -0.94 (log10 µM)
Synonyms: THP-1, THP1
WM1158: -0.96 (log10 µM)
Synonyms: WM1158
KON: -0.98 (log10 µM)
Synonyms: KON
786-0: -0.99 (log10 µM)
Synonyms: 786-0, 786-O, 786-o, 786O
VMRC-RCW: -1.02 (log10 µM)
Synonyms: VMRC-RCW, VMRCRCW
KASUMI-1: -1.03 (log10 µM)
Synonyms: KASUMI-1, Kasumi-1, KASUMI1
KM12: -1.05 (log10 µM)
Synonyms: KM12, KM-12
ML-2: -1.09 (log10 µM)
Synonyms: ML-2, ML2
JSC-1: -1.10 (log10 µM)
Synonyms: JSC-1
HPAC: -1.17 (log10 µM)
Synonyms: HPAC
NB4: -1.18 (log10 µM)
Synonyms: NB4, NB-4
REH: -1.18 (log10 µM)
Synonyms: REH, Reh
NCI-H3122: -1.20 (log10 µM)
Synonyms: NCI-H3122
A4-Fuk: -1.22 (log10 µM)
Synonyms: A4-Fuk, A4/Fuk, A4_Fuk, A4FUK
NALM-6: -1.27 (log10 µM)
Synonyms: NALM-6, NALM6
IA-LM: -1.28 (log10 µM)
Synonyms: IA-LM, IALM
IHH-4: -1.36 (log10 µM)
Synonyms: IHH-4
MOLP-8: -1.58 (log10 µM)
Synonyms: MOLP-8, MOLP8
SIG-M5: -1.62 (log10 µM)
Synonyms: SIG-M5, SIGM5
Daoy: -1.66 (log10 µM)
Synonyms: Daoy, DAOY
SNU-398: -1.90 (log10 µM)
Synonyms: SNU-398, SNU398
QIMR-WIL: -1.91 (log10 µM)
Synonyms: QIMR-WIL
MEL-JUSO: -1.91 (log10 µM)
Synonyms: MEL-JUSO, MELJUSO
NCI-H847: -3.26 (log10 µM)
Synonyms: NCI-H847
RPMI-6666: -4.16 (log10 µM)
Synonyms: RPMI-6666, RPMI6666
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
Tipifarnib: AAC
AAC
Tissues
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
0.80
0.90
gastrointestinal_tract_(site_indeterminate)
gastrointestinal_tract_(site_indeterminate)
pleura
pleura
autonomic_ganglia
autonomic_ganglia
head_and_neck
head_and_neck
placenta
placenta
cervix
cervix
central_nervous_system
central_nervous_system
ovary
ovary
lung
lung
testis
testis
breast
breast
prostate
prostate
large_intestine
large_intestine
kidney
kidney
adrenal_gland
adrenal_gland
pancreas
pancreas
liver
liver
urinary_tract
urinary_tract
bone
bone
upper_aerodigestive_tract
upper_aerodigestive_tract
soft_tissue
soft_tissue
oral_cavity
oral_cavity
stomach
stomach
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
skin
skin
thyroid
thyroid
endometrium
endometrium
biliary_tract
biliary_tract
oesophagus
oesophagus
neuroblastoma
neuroblastoma
vulva
vulva
salivary_gland
salivary_gland
other
other
misc
misc
small_intestine
small_intestine
-5.00
-4.00
-3.00
-2.00
-1.00
0.00
1.00
2.00
3.00
4.00
small_intestine
small_intestine
misc
misc
other
other
salivary_gland
salivary_gland
vulva
vulva
oesophagus
oesophagus
skin
skin
thyroid
thyroid
neuroblastoma
neuroblastoma
liver
liver
endometrium
endometrium
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
stomach
stomach
adrenal_gland
adrenal_gland
head_and_neck
head_and_neck
prostate
prostate
ovary
ovary
upper_aerodigestive_tract
upper_aerodigestive_tract
large_intestine
large_intestine
urinary_tract
urinary_tract
kidney
kidney
placenta
placenta
bone
bone
biliary_tract
biliary_tract
pancreas
pancreas
breast
breast
central_nervous_system
central_nervous_system
oral_cavity
oral_cavity
lung
lung
soft_tissue
soft_tissue
pleura
pleura
cervix
cervix
autonomic_ganglia
autonomic_ganglia
testis
testis
gastrointestinal_tract_(site_indeterminate)
gastrointestinal_tract_(site_indeterminate)
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to Tipifarnib
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
FXYD5
GDSC1000
pan-cancer
AAC
0.088
0.02
mRNA
MINA
GDSC1000
pan-cancer
AAC
0.08
0.02
mRNA
SLC46A3
FIMM
pan-cancer
AAC
-0.28
0.02
mRNA
ING3
FIMM
pan-cancer
AAC
0.4
0.02
mRNA
GPR161
GDSC1000
pan-cancer
AAC
-0.09
0.02
mRNA
E2F5
GDSC1000
pan-cancer
AAC
0.084
0.02
mRNA
PRDM16
FIMM
pan-cancer
AAC
0.33
0.02
mRNA
BAHCC1
GDSC1000
pan-cancer
AAC
0.081
0.02
mRNA
CDC42EP1
GDSC1000
pan-cancer
AAC
0.085
0.02
mRNA
S100A4
GDSC1000
pan-cancer
AAC
0.081
0.02
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