PharmacoDB

Sources

Names Used

AP-24534

Ponatinib

PharmacoGx

AP-24534

Database	Identifier
Smiles:	CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Inchikey:	PHXJVRSECIGDHY-UHFFFAOYSA-N
Pubchem:	24826799

Database

Identifier

Smiles:

CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5

Inchikey:

PHXJVRSECIGDHY-UHFFFAOYSA-N

Pubchem:

Top molecular features associated with response to AP-24534

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	WASF1	FIMM	pan-cancer	AAC	0.47	0.002
mRNA	LIMD2	FIMM	pan-cancer	AAC	0.57	0.003
mRNA	HAPLN1	FIMM	pan-cancer	AAC	0.56	0.003
mRNA	MAGEC3	FIMM	pan-cancer	AAC	0.47	0.003
mRNA	CSF3R	FIMM	pan-cancer	AAC	0.69	0.003
mRNA	CD47	FIMM	pan-cancer	AAC	-0.5	0.003
mRNA	CD101	FIMM	pan-cancer	AAC	-0.48	0.003
mRNA	TNFSF4	FIMM	pan-cancer	AAC	0.48	0.003
mRNA	ATP8A2	FIMM	pan-cancer	AAC	0.48	0.003
mRNA	MYO9B	FIMM	pan-cancer	AAC	0.54	0.003