PharmacoDB

Sources

Names Used

AP-24534

Ponatinib

PharmacoGx

AP-24534

Database	Identifier
Smiles:	CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Inchikey:	PHXJVRSECIGDHY-UHFFFAOYSA-N
Pubchem:	24826799

Database

Identifier

Smiles:

CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5

Inchikey:

PHXJVRSECIGDHY-UHFFFAOYSA-N

Pubchem:

Top molecular features associated with response to AP-24534

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	MPP2	FIMM	pan-cancer	AAC	-0.44	0.01
mRNA	HOMER1	FIMM	pan-cancer	AAC	-0.44	0.006
mRNA	NHLH1	FIMM	pan-cancer	AAC	-0.44	0.008
mRNA	TFIP11	FIMM	pan-cancer	AAC	-0.43	0.006
mRNA	CCL22	FIMM	pan-cancer	AAC	-0.43	0.007
mRNA	PQLC3	FIMM	pan-cancer	AAC	-0.43	0.007
mRNA	PCOLCE2	FIMM	pan-cancer	AAC	-0.43	0.02
mRNA	STXBP1	FIMM	pan-cancer	AAC	-0.42	0.01
mRNA	KLK1	FIMM	pan-cancer	AAC	-0.42	0.01
mRNA	RUBCNL	FIMM	pan-cancer	AAC	-0.42	0.02