PharmacoDB

Sources

Names Used

AP-24534

Ponatinib

PharmacoGx

AP-24534

Database	Identifier
Smiles:	CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Inchikey:	PHXJVRSECIGDHY-UHFFFAOYSA-N
Pubchem:	24826799

Database

Identifier

Smiles:

CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5

Inchikey:

PHXJVRSECIGDHY-UHFFFAOYSA-N

Pubchem:

Top molecular features associated with response to AP-24534

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	KDM6A	FIMM	pan-cancer	AAC	0.51	0.001
mRNA	DNASE2B	FIMM	pan-cancer	AAC	0.55	0.001
mRNA	VCL	FIMM	pan-cancer	AAC	0.58	0.001
mRNA	C22orf46	FIMM	pan-cancer	AAC	-0.6	0.001
mRNA	DSCR4	FIMM	pan-cancer	AAC	-0.51	0.001
mRNA	CCNK	FIMM	pan-cancer	AAC	0.6	0.001
mRNA	DEAF1	FIMM	pan-cancer	AAC	0.55	0.001
mRNA	MMRN2	FIMM	pan-cancer	AAC	0.5	0.001
mRNA	ARHGEF26	FIMM	pan-cancer	AAC	0.52	0.001
mRNA	MAX	FIMM	pan-cancer	AAC	0.55	0.001