PharmacoDB

Sources

Names Used

AP-24534

Ponatinib

PharmacoGx

AP-24534

Database	Identifier
Smiles:	CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Inchikey:	PHXJVRSECIGDHY-UHFFFAOYSA-N
Pubchem:	24826799

Database

Identifier

Smiles:

CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5

Inchikey:

PHXJVRSECIGDHY-UHFFFAOYSA-N

Pubchem:

Top molecular features associated with response to AP-24534

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	GALNT1	FIMM	pan-cancer	AAC	0.58	0.002
mRNA	VCL	FIMM	pan-cancer	AAC	0.58	0.001
mRNA	GPX4	FIMM	pan-cancer	AAC	0.58	0.007
mRNA	STAP1	FIMM	pan-cancer	AAC	0.58	0.002
mRNA	PPIP5K2	FIMM	pan-cancer	AAC	0.59	0.006
mRNA	P2RY1	FIMM	pan-cancer	AAC	0.6	0.0006
mRNA	DLK1	FIMM	pan-cancer	AAC	0.6	0.0007
mRNA	CCNK	FIMM	pan-cancer	AAC	0.6	0.001
mRNA	RRP8	FIMM	pan-cancer	AAC	0.6	0.004
mRNA	BAAT	FIMM	pan-cancer	AAC	0.62	0.0001