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AP-24534

AP-24534

Synonyms

Sources	Names Used
GDSC1000	AP-24534
FIMM	Ponatinib
PharmacoGx	AP-24534

External IDs

Database	Identifier
Smiles:	CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Inchikey:	PHXJVRSECIGDHY-UHFFFAOYSA-N
Pubchem:	24826799

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to AP-24534

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	KHSRP	GDSC1000	pan-cancer	AAC	0.08	0.02
mRNA	RPP40	GDSC1000	pan-cancer	AAC	0.077	0.02
mRNA	ASB13	GDSC1000	pan-cancer	AAC	0.079	0.02
mRNA	CORO1A	GDSC1000	pan-cancer	AAC	0.14	0.02
mRNA	ABCB4	FIMM	pan-cancer	AAC	0.41	0.02
mRNA	KIAA1456	GDSC1000	pan-cancer	AAC	-0.09	0.02
mRNA	MYC	GDSC1000	pan-cancer	AAC	0.089	0.02
mRNA	OR14J1	GDSC1000	pan-cancer	AAC	0.077	0.02
mRNA	CFAP53	GDSC1000	pan-cancer	AAC	-0.076	0.02
mRNA	UFM1	FIMM	pan-cancer	AAC	-0.39	0.02

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