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AP-24534

Synonyms

SourcesNames Used
GDSC1000AP-24534
FIMMPonatinib
PharmacoGx AP-24534

External IDs

DatabaseIdentifier
Smiles: CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Inchikey: PHXJVRSECIGDHY-UHFFFAOYSA-N
Pubchem: 24826799

FDA Approval Status

Approved
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Top molecular features associated with response to AP-24534


Feature TypeStandardized
Nominal ANOVA
mRNA COL4A2 GDSC1000 pan-cancer AAC -0.096 0.02
mRNA DUSP8 GDSC1000 pan-cancer AAC -0.079 0.02
mRNA ZNF554 GDSC1000 pan-cancer AAC 0.076 0.02
mRNA OSBPL2 GDSC1000 pan-cancer AAC -0.084 0.02
mRNA ZNF569 GDSC1000 pan-cancer AAC 0.082 0.02
mRNA TRIM25 FIMM pan-cancer AAC -0.38 0.02
mRNA SIGLEC5 FIMM pan-cancer AAC 0.42 0.02
mRNA TAP1 GDSC1000 pan-cancer AAC -0.088 0.02
mRNA ZNF555 GDSC1000 pan-cancer AAC 0.076 0.02
mRNA CMTM5 GDSC1000 pan-cancer AAC 0.078 0.02
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