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AP-24534

AP-24534

Synonyms

Sources	Names Used
GDSC1000	AP-24534
FIMM	Ponatinib
PharmacoGx	AP-24534

External IDs

Database	Identifier
Smiles:	CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Inchikey:	PHXJVRSECIGDHY-UHFFFAOYSA-N
Pubchem:	24826799

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to AP-24534

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	KDM5D	FIMM	pan-cancer	AAC	-0.46	0.02
mRNA	PCID2	FIMM	pan-cancer	AAC	0.42	0.02
mRNA	DCAF8L2	GDSC1000	pan-cancer	AAC	0.076	0.02
mRNA	SLC43A2	GDSC1000	pan-cancer	AAC	0.081	0.02
mRNA	WDR6	GDSC1000	pan-cancer	AAC	0.081	0.02
mRNA	VASP	GDSC1000	pan-cancer	AAC	0.083	0.02
mRNA	MET	GDSC1000	pan-cancer	AAC	-0.095	0.02
mRNA	COLGALT1	GDSC1000	pan-cancer	AAC	0.083	0.02
mRNA	TSEN15	GDSC1000	pan-cancer	AAC	-0.082	0.02
mRNA	RHBDD1	GDSC1000	pan-cancer	AAC	-0.081	0.02

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