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AP-24534

AP-24534

Synonyms

Sources	Names Used
GDSC1000	AP-24534
FIMM	Ponatinib
PharmacoGx	AP-24534

External IDs

Database	Identifier
Smiles:	CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Inchikey:	PHXJVRSECIGDHY-UHFFFAOYSA-N
Pubchem:	24826799

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to AP-24534

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	HBG2	GDSC1000	pan-cancer	AAC	0.13	0.0001
mRNA	MILR1	GDSC1000	pan-cancer	AAC	0.13	0.0001
mRNA	NFKBIA	GDSC1000	pan-cancer	AAC	-0.13	0.0001
mRNA	ZNF160	GDSC1000	pan-cancer	AAC	0.13	0.0001
mRNA	MGST3	GDSC1000	pan-cancer	AAC	-0.14	0.0001
mRNA	ADGRE2	GDSC1000	pan-cancer	AAC	0.14	0.0001
mRNA	AP5B1	GDSC1000	pan-cancer	AAC	0.13	0.0001
mRNA	CNOT8	GDSC1000	pan-cancer	AAC	0.13	0.0001
mRNA	BAAT	FIMM	pan-cancer	AAC	0.62	0.0001
mRNA	PRPF4B	GDSC1000	pan-cancer	AAC	0.14	0.0001

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