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AP-24534

Synonyms

SourcesNames Used
GDSC1000AP-24534
FIMMPonatinib
PharmacoGx AP-24534

External IDs

DatabaseIdentifier
Smiles: CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Inchikey: PHXJVRSECIGDHY-UHFFFAOYSA-N
Pubchem: 24826799

FDA Approval Status

Approved
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Top molecular features associated with response to AP-24534


Feature TypeStandardized
Nominal ANOVA
mRNA ZNF627 GDSC1000 pan-cancer AAC 0.15 2e-05
mRNA ADGRG5 GDSC1000 pan-cancer AAC 0.16 2e-05
mRNA ARHGEF6 GDSC1000 pan-cancer AAC 0.19 2e-05
mRNA AIF1 GDSC1000 pan-cancer AAC 0.17 2e-05
mRNA ZDHHC6 GDSC1000 pan-cancer AAC 0.14 2e-05
mRNA PRKCQ GDSC1000 pan-cancer AAC 0.15 2e-05
mRNA DUSP16 GDSC1000 pan-cancer AAC -0.15 2e-05
mRNA SOCS2 GDSC1000 pan-cancer AAC 0.14 2e-05
mRNA ATOX1 GDSC1000 pan-cancer AAC -0.15 2e-05
mRNA TBXA2R GDSC1000 pan-cancer AAC 0.14 2e-05
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