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CHIR-99021

Synonyms

SourcesNames Used
GDSC1000, CTRPv2CHIR-99021
PharmacoGx CHIR-99021

External IDs

DatabaseIdentifier
Smiles: CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
Inchikey: AQGNHMOJWBZFQQ-UHFFFAOYSA-N
Pubchem: 9956119

Annotated Targets

CDK1, GSK3A, GSK3B, MAPK1

FDA Approval Status

Not Approved
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Top molecular features associated with response to CHIR-99021


Feature TypeStandardized
Nominal ANOVA
mRNA G3BP1 GDSC1000 pan-cancer AAC 0.093 0.003
mRNA SYN2 GDSC1000 pan-cancer AAC -0.11 0.003
mRNA ALPK2 GDSC1000 pan-cancer AAC 0.11 0.003
mRNA CAMLG GDSC1000 pan-cancer AAC 0.096 0.003
mRNA CTNNA1 GDSC1000 pan-cancer AAC 0.12 0.003
mRNA NEXN CTRPv2 pan-cancer AAC 0.11 0.003
mRNA XRCC4 GDSC1000 pan-cancer AAC 0.097 0.003
mRNA ZWINT GDSC1000 pan-cancer AAC -0.096 0.003
mRNA ZNF141 GDSC1000 pan-cancer AAC -0.095 0.003
mRNA SERPINI2 CTRPv2 pan-cancer AAC -0.099 0.003
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