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CHIR-99021

Synonyms

SourcesNames Used
GDSC1000, CTRPv2CHIR-99021
PharmacoGx CHIR-99021

External IDs

DatabaseIdentifier
Smiles: CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
Inchikey: AQGNHMOJWBZFQQ-UHFFFAOYSA-N
Pubchem: 9956119

Annotated Targets

CDK1, GSK3A, GSK3B, MAPK1

FDA Approval Status

Not Approved
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Top molecular features associated with response to CHIR-99021


Feature TypeStandardized
Nominal ANOVA
mRNA SHC1 GDSC1000 pan-cancer AAC 0.21 5e-09
mRNA FAM129C CTRPv2 pan-cancer AAC 0.2 6e-09
mRNA EVA1B GDSC1000 pan-cancer AAC 0.19 7e-09
mRNA ITGB1 GDSC1000 pan-cancer AAC 0.23 7e-09
mRNA KIAA1456 GDSC1000 pan-cancer AAC -0.21 8e-09
mRNA GFPT2 GDSC1000 pan-cancer AAC 0.2 8e-09
mRNA IER5L GDSC1000 pan-cancer AAC 0.21 9e-09
mRNA CHN2 GDSC1000 pan-cancer AAC -0.18 9e-09
mRNA SV2B GDSC1000 pan-cancer AAC -0.19 9e-09
mRNA RRAS GDSC1000 pan-cancer AAC 0.23 1e-08
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