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CHIR-99021

Synonyms

SourcesNames Used
GDSC1000, CTRPv2CHIR-99021
PharmacoGx CHIR-99021

External IDs

DatabaseIdentifier
Smiles: CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
Inchikey: AQGNHMOJWBZFQQ-UHFFFAOYSA-N
Pubchem: 9956119

Annotated Targets

CDK1, GSK3A, GSK3B, MAPK1

FDA Approval Status

Not Approved
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Top molecular features associated with response to CHIR-99021


Feature TypeStandardized
Nominal ANOVA
mRNA ERRFI1 GDSC1000 pan-cancer AAC 0.29 4e-10
mRNA PPFIBP1 GDSC1000 pan-cancer AAC 0.22 6e-10
mRNA YAP1 GDSC1000 pan-cancer AAC 0.28 8e-10
mRNA BCAR3 GDSC1000 pan-cancer AAC 0.22 1e-09
mRNA TCL1A CTRPv2 pan-cancer AAC 0.21 1e-09
mRNA DOCK1 GDSC1000 pan-cancer AAC 0.22 2e-09
mRNA CRIM1 GDSC1000 pan-cancer AAC 0.23 3e-09
mRNA PHLDA1 GDSC1000 pan-cancer AAC 0.23 3e-09
mRNA RIN1 GDSC1000 pan-cancer AAC 0.19 4e-09
mRNA HADH GDSC1000 pan-cancer AAC -0.2 5e-09
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