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Compounds
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Midostaurin
Midostaurin
Synonyms
Sources
Names Used
GDSC1000
Midostaurin
PharmacoGx
Midostaurin
External IDs
Database
Identifier
Smiles:
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC
Inchikey:
BMGQWWVMWDBQGC-PZFYLCKJSA-N
Pubchem:
24202429
Annotated Targets
KIT
,
FLT3
,
PRKCG
FDA Approval Status
Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with
Midostaurin (per dataset)
0
100
200
300
400
500
600
700
800
900
# cell lines
CCLE
gCSI
GRAY
FIMM
CTRPv2
UHNBreast
GDSC1000
0
0
0
0
0
0
941
Download SVG
Number of tissues tested with Midostaurin
(per dataset)
0
5
10
15
20
25
30
35
# tissues
CCLE
gCSI
GRAY
FIMM
CTRPv2
UHNBreast
GDSC1000
0
0
0
0
0
0
35
Download SVG
Dataset Select
all
GDSC1000
Midostaurin: AAC
AAC
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
0.55
MV-4-11
MV-4-11
Hs 940.T
Hs 940.T
MOLM-13
MOLM-13
ML-1
ML-1
SW982
SW982
KG-1-C
KG-1-C
NKM-1
NKM-1
CGTH-W-1
CGTH-W-1
G-292;clone A141B1
G-292;clone A141B1
NCI-H1755
NCI-H1755
EoL-1-cell
EoL-1-cell
Hs-633T
Hs-633T
TCCSUP
TCCSUP
KASUMI-1
KASUMI-1
MONO-MAC-6
MONO-MAC-6
SNU-398
SNU-398
EFM-19
EFM-19
CHSA8926
CHSA8926
MKN45
MKN45
HuO-3N1
HuO-3N1
A498
A498
NB69
NB69
KGN
KGN
DMS-273
DMS-273
NCI-H2052
NCI-H2052
SNU-387
SNU-387
A204
A204
KMRC-20
KMRC-20
KON
KON
SU-DHL-10
SU-DHL-10
SK-MEL-1
SK-MEL-1
NCI-H220
NCI-H220
SW756
SW756
TF-1
TF-1
NB1
NB1
SCLC-21H
SCLC-21H
TE-5
TE-5
NCI-H1666
NCI-H1666
NCI-SNU-5
NCI-SNU-5
RPMI-8226
RPMI-8226
ES-2
ES-2
NCI-H596
NCI-H596
NCI-H1395
NCI-H1395
NCI-H1155
NCI-H1155
SK-N-FI
SK-N-FI
HPAF-II
HPAF-II
JVM-3
JVM-3
NCI-SNU-16
NCI-SNU-16
NCI-H1385
NCI-H1385
DG-75
DG-75
COLO-320-HSR
COLO-320-HSR
PLC-PRF-5
PLC-PRF-5
HD-MY-Z
HD-MY-Z
KY821
KY821
CPC-N
CPC-N
BE2-M17
BE2-M17
TALL-1
TALL-1
NCI-H1876
NCI-H1876
RC-K8
RC-K8
SW837
SW837
MV-4-11
Hs 940.T
MOLM-13
ML-1
SW982
KG-1-C
NKM-1
CGTH-W-1
G-292;clone A141B1
NCI-H1755
EoL-1-cell
Hs-633T
TCCSUP
KASUMI-1
MONO-MAC-6
SNU-398
EFM-19
CHSA8926
MKN45
HuO-3N1
A498
NB69
KGN
DMS-273
NCI-H2052
SNU-387
A204
KMRC-20
KON
SU-DHL-10
SK-MEL-1
NCI-H220
SW756
TF-1
NB1
SCLC-21H
TE-5
NCI-H1666
NCI-SNU-5
RPMI-8226
ES-2
NCI-H596
NCI-H1395
NCI-H1155
SK-N-FI
HPAF-II
JVM-3
NCI-SNU-16
NCI-H1385
DG-75
COLO-320-HSR
PLC-PRF-5
HD-MY-Z
KY821
CPC-N
BE2-M17
TALL-1
NCI-H1876
RC-K8
SW837
MV-4-11: 0.57
Synonyms: MV-4-11, MV411
Hs 940.T: 0.56
Synonyms: Hs 940.T, Hs_940.T, Hs-940-T, Hs940-T, HS940T
MOLM-13: 0.55
Synonyms: MOLM-13, MOLM13
ML-1: 0.53
Synonyms: ML-1, ML1
SW982: 0.53
Synonyms: SW982, SW 982
KG-1-C: 0.52
Synonyms: KG-1-C, KG1C
NKM-1: 0.48
Synonyms: NKM-1
CGTH-W-1: 0.48
Synonyms: CGTH-W-1, CGTHW1
G-292;clone A141B1: 0.47
Synonyms: G-292;clone A141B1, G-292, clone A141B1, G-292,_clone_A141B1, G-292-Clone-A141B1, G-292 Clone A141B1, G-292_Clone_A141B1, G292CLONEA141B1
NCI-H1755: 0.43
Synonyms: NCI-H1755, NCIH1755
EoL-1-cell: 0.43
Synonyms: EoL-1-cell, EOL-1, EOL1
Hs-633T: 0.43
Synonyms: Hs-633T, Hs633T
TCCSUP: 0.42
Synonyms: TCCSUP
KASUMI-1: 0.41
Synonyms: KASUMI-1, Kasumi-1, KASUMI1
MONO-MAC-6: 0.40
Synonyms: MONO-MAC-6, MONOMAC6
SNU-398: 0.39
Synonyms: SNU-398, SNU398
EFM-19: 0.38
Synonyms: EFM-19, EFM19, efm19
CHSA8926: 0.38
Synonyms: CHSA8926
MKN45: 0.36
Synonyms: MKN45, MKN-45
HuO-3N1: 0.36
Synonyms: HuO-3N1
A498: 0.36
Synonyms: A498, A-498
NB69: 0.35
Synonyms: NB69
KGN: 0.35
Synonyms: KGN
DMS-273: 0.34
Synonyms: DMS-273, DMS 273, DMS_273, DMS273
NCI-H2052: 0.33
Synonyms: NCI-H2052, NCIH2052
SNU-387: 0.33
Synonyms: SNU-387, SNU387
A204: 0.33
Synonyms: A204, A-204
KMRC-20: 0.32
Synonyms: KMRC-20, KMRC20
KON: 0.32
Synonyms: KON
SU-DHL-10: 0.32
Synonyms: SU-DHL-10, SUDHL10
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
SK-MEL-1: 0.01
Synonyms: SK-MEL-1, SKMEL1
NCI-H220: 0.01
Synonyms: NCI-H220
SW756: 0.01
Synonyms: SW756
TF-1: 0.00
Synonyms: TF-1, TF1
NB1: 0.00
Synonyms: NB1, NB-1
SCLC-21H: 0.00
Synonyms: SCLC-21H, SCLC21H
TE-5: 0.00
Synonyms: TE-5, TE5
NCI-H1666: 0.00
Synonyms: NCI-H1666, NCIH1666
NCI-SNU-5: 0.00
Synonyms: NCI-SNU-5, SNU-5
RPMI-8226: 0.00
Synonyms: RPMI-8226, RPMI 8226, RPMI_8226, RPMI8226
ES-2: 0.00
Synonyms: ES-2, ES2
NCI-H596: 0.00
Synonyms: NCI-H596
NCI-H1395: 0.00
Synonyms: NCI-H1395, NCIH1395
NCI-H1155: 0.00
Synonyms: NCI-H1155, NCIH1155
SK-N-FI: 0.00
Synonyms: SK-N-FI, SKNFI
HPAF-II: 0.00
Synonyms: HPAF-II, HPAFII
JVM-3: 0.00
Synonyms: JVM-3, JVM3
NCI-SNU-16: 0.00
Synonyms: NCI-SNU-16, SNU-16
NCI-H1385: 0.00
Synonyms: NCI-H1385, NCIH1385
DG-75: 0.00
Synonyms: DG-75
COLO-320-HSR: 0.00
Synonyms: COLO-320-HSR, COLO-320, NA, COLO 320HSR, COLO320
PLC-PRF-5: 0.00
Synonyms: PLC-PRF-5, PLC/PRF/5, PLC_PRF_5, PLCPRF5
HD-MY-Z: 0.00
Synonyms: HD-MY-Z, HDMYZ
KY821: 0.00
Synonyms: KY821
CPC-N: 0.00
Synonyms: CPC-N
BE2-M17: 0.00
Synonyms: BE2-M17
TALL-1: 0.00
Synonyms: TALL-1, TALL1
NCI-H1876: 0.00
Synonyms: NCI-H1876
RC-K8: 0.00
Synonyms: RC-K8
SW837: 0.00
Synonyms: SW837, SW 837
Download SVG
0.00
5.00
10.00
15.00
20.00
25.00
30.00
NCI-H2052
NCI-H2052
ES6
ES6
BEN
BEN
NCI-H1836
NCI-H1836
22RV1
22RV1
Panc 02.03
Panc 02.03
EGI-1
EGI-1
SW13
SW13
GAK
GAK
OV-90
OV-90
HDLM-2
HDLM-2
RMG-I
RMG-I
Ishikawa (Heraklio) 02 ER-
Ishikawa (Heraklio) 02 ER-
NCI-H841
NCI-H841
LS-411N
LS-411N
NCI-H2110
NCI-H2110
NOMO-1
NOMO-1
LB2518-MEL
LB2518-MEL
HO-1-N-1
HO-1-N-1
BT-483
BT-483
SJSA-1
SJSA-1
NCI-H441
NCI-H441
NCI-H446
NCI-H446
ChaGo-K-1
ChaGo-K-1
LS-123
LS-123
NUGC-3
NUGC-3
GP5d
GP5d
NCI-H1092
NCI-H1092
MLMA
MLMA
L-363
L-363
TOV-112D
TOV-112D
CHSA0108
CHSA0108
MC-IXC
MC-IXC
MONO-MAC-6
MONO-MAC-6
CHP-212
CHP-212
TT2609-C02
TT2609-C02
NALM-6
NALM-6
A204
A204
NCI-H2342
NCI-H2342
KM12
KM12
SNU-398
SNU-398
NB69
NB69
SW48
SW48
CAL-51
CAL-51
A427
A427
MES-SA
MES-SA
KMRC-20
KMRC-20
LC-2-ad
LC-2-ad
KASUMI-1
KASUMI-1
G-292;clone A141B1
G-292;clone A141B1
EoL-1-cell
EoL-1-cell
Hs-633T
Hs-633T
CGTH-W-1
CGTH-W-1
NKM-1
NKM-1
NCI-H1755
NCI-H1755
KG-1-C
KG-1-C
SW982
SW982
MOLM-13
MOLM-13
MV-4-11
MV-4-11
Hs 940.T
Hs 940.T
NCI-H2052
ES6
BEN
NCI-H1836
22RV1
Panc 02.03
EGI-1
SW13
GAK
OV-90
HDLM-2
RMG-I
Ishikawa (Heraklio) 02 ER-
NCI-H841
LS-411N
NCI-H2110
NOMO-1
LB2518-MEL
HO-1-N-1
BT-483
SJSA-1
NCI-H441
NCI-H446
ChaGo-K-1
LS-123
NUGC-3
GP5d
NCI-H1092
MLMA
L-363
TOV-112D
CHSA0108
MC-IXC
MONO-MAC-6
CHP-212
TT2609-C02
NALM-6
A204
NCI-H2342
KM12
SNU-398
NB69
SW48
CAL-51
A427
MES-SA
KMRC-20
LC-2-ad
KASUMI-1
G-292;clone A141B1
EoL-1-cell
Hs-633T
CGTH-W-1
NKM-1
NCI-H1755
KG-1-C
SW982
MOLM-13
MV-4-11
Hs 940.T
NCI-H2052: 31.43 (log10 µM)
Synonyms: NCI-H2052, NCIH2052
ES6: 11.96 (log10 µM)
Synonyms: ES6
BEN: 10.40 (log10 µM)
Synonyms: BEN
NCI-H1836: 9.27 (log10 µM)
Synonyms: NCI-H1836
22RV1: 6.00 (log10 µM)
Synonyms: 22RV1, 22Rv1
Panc 02.03: 6.00 (log10 µM)
Synonyms: Panc 02.03, Panc_02.03, PANC-02-03, PANC0203
EGI-1: 6.00 (log10 µM)
Synonyms: EGI-1
SW13: 5.63 (log10 µM)
Synonyms: SW13
GAK: 5.40 (log10 µM)
Synonyms: GAK
OV-90: 5.38 (log10 µM)
Synonyms: OV-90, OV90
HDLM-2: 5.11 (log10 µM)
Synonyms: HDLM-2, HDLM2
RMG-I: 4.46 (log10 µM)
Synonyms: RMG-I, RMGI
Ishikawa (Heraklio) 02 ER-: 4.45 (log10 µM)
Synonyms: Ishikawa (Heraklio) 02 ER-, Ishikawa__Heraklio__02_ER-, Ishikawa_Heraklio_02ER-, ISHIKAWAHERAKLIO02ER
NCI-H841: 4.31 (log10 µM)
Synonyms: NCI-H841, NCIH841
LS-411N: 4.31 (log10 µM)
Synonyms: LS-411N, LS411N
NCI-H2110: 4.20 (log10 µM)
Synonyms: NCI-H2110, NCIH2110
NOMO-1: 4.18 (log10 µM)
Synonyms: NOMO-1, NOMO1
LB2518-MEL: 3.80 (log10 µM)
Synonyms: LB2518-MEL
HO-1-N-1: 3.61 (log10 µM)
Synonyms: HO-1-N-1
BT-483: 3.49 (log10 µM)
Synonyms: BT-483, BT483, bt483
SJSA-1: 3.26 (log10 µM)
Synonyms: SJSA-1, SJSA1
NCI-H441: 3.24 (log10 µM)
Synonyms: NCI-H441, NCIH441
NCI-H446: 2.99 (log10 µM)
Synonyms: NCI-H446, NCIH446
ChaGo-K-1: 2.97 (log10 µM)
Synonyms: ChaGo-K-1, CHAGOK1
LS-123: 2.82 (log10 µM)
Synonyms: LS-123, LS123
NUGC-3: 2.73 (log10 µM)
Synonyms: NUGC-3, NUGC3
GP5d: 2.70 (log10 µM)
Synonyms: GP5d
NCI-H1092: 2.53 (log10 µM)
Synonyms: NCI-H1092, NCIH1092
MLMA: 2.52 (log10 µM)
Synonyms: MLMA
L-363: 2.31 (log10 µM)
Synonyms: L-363, L363
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
TOV-112D: -0.93 (log10 µM)
Synonyms: TOV-112D, TOV112D
CHSA0108: -0.94 (log10 µM)
Synonyms: CHSA0108
MC-IXC: -0.94 (log10 µM)
Synonyms: MC-IXC
MONO-MAC-6: -0.94 (log10 µM)
Synonyms: MONO-MAC-6, MONOMAC6
CHP-212: -0.95 (log10 µM)
Synonyms: CHP-212, CHP212
TT2609-C02: -0.96 (log10 µM)
Synonyms: TT2609-C02, TT2609C02
NALM-6: -0.99 (log10 µM)
Synonyms: NALM-6, NALM6
A204: -1.00 (log10 µM)
Synonyms: A204, A-204
NCI-H2342: -1.00 (log10 µM)
Synonyms: NCI-H2342, NCIH2342
KM12: -1.01 (log10 µM)
Synonyms: KM12, KM-12
SNU-398: -1.03 (log10 µM)
Synonyms: SNU-398, SNU398
NB69: -1.04 (log10 µM)
Synonyms: NB69
SW48: -1.04 (log10 µM)
Synonyms: SW48, SW 48
CAL-51: -1.05 (log10 µM)
Synonyms: CAL-51, CAL51, cal51
A427: -1.06 (log10 µM)
Synonyms: A427, A-427
MES-SA: -1.06 (log10 µM)
Synonyms: MES-SA, MESSA
KMRC-20: -1.07 (log10 µM)
Synonyms: KMRC-20, KMRC20
LC-2-ad: -1.07 (log10 µM)
Synonyms: LC-2-ad
KASUMI-1: -1.24 (log10 µM)
Synonyms: KASUMI-1, Kasumi-1, KASUMI1
G-292;clone A141B1: -1.30 (log10 µM)
Synonyms: G-292;clone A141B1, G-292, clone A141B1, G-292,_clone_A141B1, G-292-Clone-A141B1, G-292 Clone A141B1, G-292_Clone_A141B1, G292CLONEA141B1
EoL-1-cell: -1.32 (log10 µM)
Synonyms: EoL-1-cell, EOL-1, EOL1
Hs-633T: -1.36 (log10 µM)
Synonyms: Hs-633T, Hs633T
CGTH-W-1: -1.42 (log10 µM)
Synonyms: CGTH-W-1, CGTHW1
NKM-1: -1.43 (log10 µM)
Synonyms: NKM-1
NCI-H1755: -1.47 (log10 µM)
Synonyms: NCI-H1755, NCIH1755
KG-1-C: -1.60 (log10 µM)
Synonyms: KG-1-C, KG1C
SW982: -1.62 (log10 µM)
Synonyms: SW982, SW 982
MOLM-13: -1.66 (log10 µM)
Synonyms: MOLM-13, MOLM13
MV-4-11: -1.68 (log10 µM)
Synonyms: MV-4-11, MV411
Hs 940.T: -1.71 (log10 µM)
Synonyms: Hs 940.T, Hs_940.T, Hs-940-T, Hs940-T, HS940T
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
Midostaurin: AAC
AAC
Tissues
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
0.55
neuroblastoma
neuroblastoma
gastrointestinal_tract_(site_indeterminate)
gastrointestinal_tract_(site_indeterminate)
testis
testis
cervix
cervix
autonomic_ganglia
autonomic_ganglia
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
breast
breast
prostate
prostate
stomach
stomach
lung
lung
large_intestine
large_intestine
ovary
ovary
endometrium
endometrium
pancreas
pancreas
oesophagus
oesophagus
salivary_gland
salivary_gland
vulva
vulva
urinary_tract
urinary_tract
liver
liver
upper_aerodigestive_tract
upper_aerodigestive_tract
skin
skin
bone
bone
adrenal_gland
adrenal_gland
head_and_neck
head_and_neck
soft_tissue
soft_tissue
pleura
pleura
biliary_tract
biliary_tract
thyroid
thyroid
central_nervous_system
central_nervous_system
placenta
placenta
oral_cavity
oral_cavity
kidney
kidney
small_intestine
small_intestine
other
other
misc
misc
-1.00
0.00
1.00
2.00
3.00
4.00
5.00
6.00
misc
misc
small_intestine
small_intestine
soft_tissue
soft_tissue
salivary_gland
salivary_gland
oesophagus
oesophagus
kidney
kidney
thyroid
thyroid
bone
bone
central_nervous_system
central_nervous_system
pancreas
pancreas
ovary
ovary
liver
liver
cervix
cervix
endometrium
endometrium
urinary_tract
urinary_tract
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
biliary_tract
biliary_tract
skin
skin
pleura
pleura
prostate
prostate
upper_aerodigestive_tract
upper_aerodigestive_tract
lung
lung
head_and_neck
head_and_neck
breast
breast
stomach
stomach
neuroblastoma
neuroblastoma
autonomic_ganglia
autonomic_ganglia
large_intestine
large_intestine
vulva
vulva
oral_cavity
oral_cavity
placenta
placenta
gastrointestinal_tract_(site_indeterminate)
gastrointestinal_tract_(site_indeterminate)
other
other
testis
testis
adrenal_gland
adrenal_gland
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to Midostaurin
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
FOSL1
GDSC1000
pan-cancer
AAC
0.16
2e-05
mRNA
MMAB
GDSC1000
pan-cancer
AAC
-0.14
2e-05
mRNA
POLR2L
GDSC1000
pan-cancer
AAC
0.16
2e-05
mRNA
PAPSS2
GDSC1000
pan-cancer
AAC
0.16
2e-05
mRNA
UNC13A
GDSC1000
pan-cancer
AAC
-0.16
2e-05
mRNA
TGFB1I1
GDSC1000
pan-cancer
AAC
0.18
2e-05
mRNA
PCSK2
GDSC1000
pan-cancer
AAC
-0.15
2e-05
mRNA
MANEAL
GDSC1000
pan-cancer
AAC
-0.15
2e-05
mRNA
TPM2
GDSC1000
pan-cancer
AAC
0.16
2e-05
mRNA
AP3M2
GDSC1000
pan-cancer
AAC
-0.15
2e-05
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