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Roscovitine

Roscovitine

Synonyms

Sources	Names Used
GDSC1000	Roscovitine
FIMM	Seliciclib
PharmacoGx	Roscovitine

External IDs

Database	Identifier
Smiles:	CCC(CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C
Inchikey:	BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Pubchem:	160355

Annotated Targets

CDK2, CDK9

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to Roscovitine

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	COPA	GDSC1000	pan-cancer	AAC	0.21	5e-05
mRNA	CACNA1C	FIMM	pan-cancer	AAC	0.6	5e-05
mRNA	LRAT	FIMM	pan-cancer	AAC	0.59	6e-05
mRNA	CAP2	GDSC1000	pan-cancer	AAC	0.29	0.0001
mRNA	OOEP	GDSC1000	pan-cancer	AAC	0.2	0.0001
mRNA	POLD3	GDSC1000	pan-cancer	AAC	-0.21	0.0001
mRNA	BATF2	GDSC1000	pan-cancer	AAC	0.19	0.0001
mRNA	SAMD4A	GDSC1000	pan-cancer	AAC	0.21	0.0001
mRNA	UNG	GDSC1000	pan-cancer	AAC	-0.2	0.0002
mRNA	PTBP1	GDSC1000	pan-cancer	AAC	-0.21	0.0002

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