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Roscovitine

Roscovitine

Synonyms

Sources	Names Used
GDSC1000	Roscovitine
FIMM	Seliciclib
PharmacoGx	Roscovitine

External IDs

Database	Identifier
Smiles:	CCC(CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C
Inchikey:	BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Pubchem:	160355

Annotated Targets

CDK2, CDK9

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to Roscovitine

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	HNRNPF	GDSC1000	pan-cancer	AAC	-0.18	0.002
mRNA	PAM	FIMM	pan-cancer	AAC	0.49	0.002
mRNA	SRSF2	GDSC1000	pan-cancer	AAC	-0.18	0.002
mRNA	LRRN3	GDSC1000	pan-cancer	AAC	-0.2	0.002
mRNA	DDX39A	GDSC1000	pan-cancer	AAC	-0.18	0.002
mRNA	ZCCHC24	GDSC1000	pan-cancer	AAC	0.18	0.002
mRNA	KANSL1	GDSC1000	pan-cancer	AAC	-0.18	0.002
mRNA	XRCC5	GDSC1000	pan-cancer	AAC	-0.17	0.002
mRNA	GOLPH3L	GDSC1000	pan-cancer	AAC	0.17	0.002
mRNA	MPP1	FIMM	pan-cancer	AAC	0.81	0.003

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