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Roscovitine

Roscovitine

Synonyms

Sources	Names Used
GDSC1000	Roscovitine
FIMM	Seliciclib
PharmacoGx	Roscovitine

External IDs

Database	Identifier
Smiles:	CCC(CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C
Inchikey:	BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Pubchem:	160355

Annotated Targets

CDK2, CDK9

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to Roscovitine

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	SETD4	FIMM	pan-cancer	AAC	-0.33	0.04
mRNA	PHGDH	FIMM	pan-cancer	AAC	-0.33	0.04
mRNA	ZC3H18	GDSC1000	pan-cancer	AAC	-0.11	0.04
mRNA	RNF212	GDSC1000	pan-cancer	AAC	-0.11	0.04
mRNA	TNFRSF9	FIMM	pan-cancer	AAC	0.35	0.04
mRNA	POLE2	GDSC1000	pan-cancer	AAC	-0.11	0.04
mRNA	LRRTM2	FIMM	pan-cancer	AAC	0.36	0.04
mRNA	EXOC6	GDSC1000	pan-cancer	AAC	-0.11	0.04
mRNA	FXR2	FIMM	pan-cancer	AAC	0.42	0.04
mRNA	BUB3	FIMM	pan-cancer	AAC	-0.34	0.04

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