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Roscovitine

Roscovitine

Synonyms

Sources	Names Used
GDSC1000	Roscovitine
FIMM	Seliciclib
PharmacoGx	Roscovitine

External IDs

Database	Identifier
Smiles:	CCC(CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C
Inchikey:	BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Pubchem:	160355

Annotated Targets

CDK2, CDK9

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to Roscovitine

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	UHMK1	GDSC1000	pan-cancer	AAC	0.18	0.002
mRNA	HTRA3	GDSC1000	pan-cancer	AAC	0.16	0.002
mRNA	CPA3	FIMM	pan-cancer	AAC	0.48	0.002
mRNA	EMC7	GDSC1000	pan-cancer	AAC	0.16	0.002
mRNA	VAV2	GDSC1000	pan-cancer	AAC	-0.18	0.002
mRNA	SCARF1	FIMM	pan-cancer	AAC	0.53	0.002
mRNA	FHL3	FIMM	pan-cancer	AAC	0.53	0.002
mRNA	FAM189B	GDSC1000	pan-cancer	AAC	0.18	0.002
mRNA	ATP6V0A2	GDSC1000	pan-cancer	AAC	-0.21	0.002
mRNA	SMIM4	GDSC1000	pan-cancer	AAC	0.17	0.002

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