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Roscovitine

Roscovitine

Synonyms

Sources	Names Used
GDSC1000	Roscovitine
FIMM	Seliciclib
PharmacoGx	Roscovitine

External IDs

Database	Identifier
Smiles:	CCC(CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C
Inchikey:	BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Pubchem:	160355

Annotated Targets

CDK2, CDK9

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to Roscovitine

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	FAHD1	GDSC1000	pan-cancer	AAC	0.19	0.0009
mRNA	PROX2	GDSC1000	pan-cancer	AAC	0.17	0.0009
mRNA	CTSZ	GDSC1000	pan-cancer	AAC	0.2	0.001
mRNA	ADAR	GDSC1000	pan-cancer	AAC	0.18	0.001
mRNA	SDHC	GDSC1000	pan-cancer	AAC	0.18	0.001
mRNA	ITGAV	GDSC1000	pan-cancer	AAC	0.25	0.001
mRNA	AP3M1	GDSC1000	pan-cancer	AAC	-0.19	0.001
mRNA	SELM	GDSC1000	pan-cancer	AAC	0.19	0.001
mRNA	CWF19L1	GDSC1000	pan-cancer	AAC	-0.19	0.001
mRNA	FEM1B	GDSC1000	pan-cancer	AAC	0.18	0.001

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