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Nutlin-3

Synonyms

SourcesNames Used
CCLENutlin-3
GRAYNutlin 3a
CTRPv2nutlin-3
PharmacoGx Nutlin-3

External IDs

DatabaseIdentifier
Smiles: CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Inchikey: BDUHCSBCVGXTJM-UHFFFAOYSA-N
Pubchem: 216345

Annotated Targets

MDM2, TP53

FDA Approval Status

Not Approved
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Top molecular features associated with response to Nutlin-3


Feature TypeStandardized
Nominal ANOVA
mRNA MDM4 CTRPv2 pan-cancer AAC 0.24 1e-09
mRNA TRIM22 CTRPv2 pan-cancer AAC 0.22 2e-09
mRNA TPX2 CTRPv2 pan-cancer AAC -0.2 2e-09
mRNA RPL13A CTRPv2 pan-cancer AAC 0.23 2e-09
mRNA PHF20 CTRPv2 pan-cancer AAC -0.2 3e-09
mRNA NELFE CTRPv2 pan-cancer AAC -0.2 5e-09
mRNA HNRNPA1 CTRPv2 pan-cancer AAC 0.23 7e-09
mRNA RTFDC1 CTRPv2 pan-cancer AAC -0.21 1e-08
mRNA PPM1D CTRPv2 pan-cancer AAC 0.2 1e-08
mRNA RPS9 CTRPv2 pan-cancer AAC 0.23 1e-08
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