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Bortezomib

Synonyms

SourcesNames Used
GDSC1000, GRAY, FIMMBortezomib
gCSI, CTRPv2bortezomib
PharmacoGx Bortezomib

External IDs

DatabaseIdentifier
Smiles: B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
Inchikey: GXJABQQUPOEUTA-RDJZCZTQSA-N
Pubchem: 387447

Annotated Targets

PSMB2, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB1, PSMB10, PSMB11, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9, PSMD1, PSMD2, RELA

FDA Approval Status

Approved
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Top molecular features associated with response to Bortezomib


Feature TypeStandardized
Nominal ANOVA
mRNA TNNI3K gCSI pan-cancer AAC 0.15 0.009
mRNA GKN1 gCSI pan-cancer AAC 0.15 0.009
mRNA BCAS3 FIMM pan-cancer AAC -0.37 0.009
mRNA PGLYRP1 gCSI pan-cancer AAC 0.17 0.009
mRNA MED13 FIMM pan-cancer AAC -0.37 0.009
mRNA TANGO2 CTRPv2 pan-cancer AAC -0.1 0.009
mRNA AHNAK2 CTRPv2 pan-cancer AAC -0.097 0.009
mRNA SPTBN4 GDSC1000 pan-cancer AAC -0.14 0.009
mRNA TMEM135 gCSI pan-cancer AAC -0.17 0.009
mRNA FHDC1 CTRPv2 pan-cancer AAC 0.092 0.009
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