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Compounds
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BX-795
BX-795
Synonyms
Sources
Names Used
GDSC1000
BX-795
PharmacoGx
BX-795
External IDs
Database
Identifier
Smiles:
C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I
Inchikey:
VAVXGGRQQJZYBL-UHFFFAOYSA-N
Pubchem:
10077147
Annotated Targets
CDK2
,
CHEK1
,
GSK3B
,
KDR
,
PDK1
,
PDPK1
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with BX-795
(per dataset)
0
100
200
300
400
500
600
700
800
# cell lines
CCLE
gCSI
GRAY
FIMM
CTRPv2
UHNBreast
GDSC1000
0
0
0
0
0
0
889
Download SVG
Number of tissues tested with BX-795 (per
dataset)
0
5
10
15
20
25
30
35
# tissues
CCLE
gCSI
GRAY
FIMM
CTRPv2
UHNBreast
GDSC1000
0
0
0
0
0
0
35
Download SVG
Dataset Select
all
GDSC1000
BX-795: AAC
AAC
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
0.80
MV-4-11
MV-4-11
EoL-1-cell
EoL-1-cell
ALL-PO
ALL-PO
MONO-MAC-6
MONO-MAC-6
ATN-1
ATN-1
MOLM-13
MOLM-13
CGTH-W-1
CGTH-W-1
JeKo-1
JeKo-1
NALM-6
NALM-6
HUTU-80
HUTU-80
BE-13
BE-13
Hs-633T
Hs-633T
KARPAS-45
KARPAS-45
NKM-1
NKM-1
OCI-LY-7
OCI-LY-7
BV-173
BV-173
YH-13
YH-13
TOV-21G
TOV-21G
HCC-44
HCC-44
CCRF-CEM
CCRF-CEM
RCH-ACV
RCH-ACV
KYSE-30
KYSE-30
CHP-212
CHP-212
SKM-1
SKM-1
MOLT-4
MOLT-4
P30-OHK
P30-OHK
CRO-AP2
CRO-AP2
RS4;11
RS4;11
EMC-BAC-2
EMC-BAC-2
697
697
KYAE-1
KYAE-1
HT-29
HT-29
NCI-H2066
NCI-H2066
LU-65
LU-65
HC-1
HC-1
EB-3
EB-3
UDSCC2
UDSCC2
SCLC-21H
SCLC-21H
RT4
RT4
Sci-1
Sci-1
LU-165
LU-165
MDA-MB-330
MDA-MB-330
CP66-MEL
CP66-MEL
DEL
DEL
CAPAN-1
CAPAN-1
NCI-H520
NCI-H520
MFE-280
MFE-280
OACM5-1
OACM5-1
MDA-MB-415
MDA-MB-415
JHOS-4
JHOS-4
THP-1
THP-1
COR-L95
COR-L95
LB373-MEL-D
LB373-MEL-D
SW1417
SW1417
MZ7-mel
MZ7-mel
JHOS-3
JHOS-3
LAN-6
LAN-6
C3A
C3A
KM-H2
KM-H2
T84
T84
MV-4-11
EoL-1-cell
ALL-PO
MONO-MAC-6
ATN-1
MOLM-13
CGTH-W-1
JeKo-1
NALM-6
HUTU-80
BE-13
Hs-633T
KARPAS-45
NKM-1
OCI-LY-7
BV-173
YH-13
TOV-21G
HCC-44
CCRF-CEM
RCH-ACV
KYSE-30
CHP-212
SKM-1
MOLT-4
P30-OHK
CRO-AP2
RS4;11
EMC-BAC-2
697
KYAE-1
HT-29
NCI-H2066
LU-65
HC-1
EB-3
UDSCC2
SCLC-21H
RT4
Sci-1
LU-165
MDA-MB-330
CP66-MEL
DEL
CAPAN-1
NCI-H520
MFE-280
OACM5-1
MDA-MB-415
JHOS-4
THP-1
COR-L95
LB373-MEL-D
SW1417
MZ7-mel
JHOS-3
LAN-6
C3A
KM-H2
T84
MV-4-11: 0.82
Synonyms: MV-4-11, MV411
EoL-1-cell: 0.77
Synonyms: EoL-1-cell, EOL-1, EOL1
ALL-PO: 0.66
Synonyms: ALL-PO
MONO-MAC-6: 0.62
Synonyms: MONO-MAC-6, MONOMAC6
ATN-1: 0.61
Synonyms: ATN-1
MOLM-13: 0.60
Synonyms: MOLM-13, MOLM13
CGTH-W-1: 0.46
Synonyms: CGTH-W-1, CGTHW1
JeKo-1: 0.44
Synonyms: JeKo-1, JEKO-1, JEKO1
NALM-6: 0.43
Synonyms: NALM-6, NALM6
HUTU-80: 0.42
Synonyms: HUTU-80, HuTu 80, HuTu_80
BE-13: 0.42
Synonyms: BE-13
Hs-633T: 0.40
Synonyms: Hs-633T, Hs633T
KARPAS-45: 0.39
Synonyms: KARPAS-45
NKM-1: 0.39
Synonyms: NKM-1
OCI-LY-7: 0.39
Synonyms: OCI-LY-7, OCI-LY7
BV-173: 0.39
Synonyms: BV-173, BV173
YH-13: 0.37
Synonyms: YH-13, YH13
TOV-21G: 0.37
Synonyms: TOV-21G, TOV21G
HCC-44: 0.36
Synonyms: HCC-44, HCC44
CCRF-CEM: 0.36
Synonyms: CCRF-CEM, CCRFCEM
RCH-ACV: 0.36
Synonyms: RCH-ACV, RCHACV
KYSE-30: 0.35
Synonyms: KYSE-30, KYSE30
CHP-212: 0.34
Synonyms: CHP-212, CHP212
SKM-1: 0.33
Synonyms: SKM-1, SKM1
MOLT-4: 0.33
Synonyms: MOLT-4
P30-OHK: 0.33
Synonyms: P30-OHK
CRO-AP2: 0.33
Synonyms: CRO-AP2
RS4;11: 0.33
Synonyms: RS4;11, RS4_11, RS4-11, RS411
EMC-BAC-2: 0.33
Synonyms: EMC-BAC-2
697: 0.32
Synonyms: 697
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
KYAE-1: 0.01
Synonyms: KYAE-1
HT-29: 0.01
Synonyms: HT-29, HT29
NCI-H2066: 0.01
Synonyms: NCI-H2066
LU-65: 0.01
Synonyms: LU-65, LU65
HC-1: 0.01
Synonyms: HC-1
EB-3: 0.01
Synonyms: EB-3
UDSCC2: 0.01
Synonyms: UDSCC2
SCLC-21H: 0.01
Synonyms: SCLC-21H, SCLC21H
RT4: 0.00
Synonyms: RT4
Sci-1: 0.00
Synonyms: Sci-1
LU-165: 0.00
Synonyms: LU-165
MDA-MB-330: 0.00
Synonyms: MDA-MB-330, mdamb330
CP66-MEL: 0.00
Synonyms: CP66-MEL
DEL: 0.00
Synonyms: DEL
CAPAN-1: 0.00
Synonyms: CAPAN-1, Capan-1, CAPAN1
NCI-H520: 0.00
Synonyms: NCI-H520, NCIH520
MFE-280: 0.00
Synonyms: MFE-280
OACM5-1: 0.00
Synonyms: OACM5-1
MDA-MB-415: 0.00
Synonyms: MDA-MB-415, MDAMB415, mdamb415
JHOS-4: 0.00
Synonyms: JHOS-4
THP-1: 0.00
Synonyms: THP-1, THP1
COR-L95: 0.00
Synonyms: COR-L95, CORL95
LB373-MEL-D: 0.00
Synonyms: LB373-MEL-D
SW1417: 0.00
Synonyms: SW1417, SW 1417
MZ7-mel: 0.00
Synonyms: MZ7-mel
JHOS-3: 0.00
Synonyms: JHOS-3
LAN-6: 0.00
Synonyms: LAN-6
C3A: 0.00
Synonyms: C3A
KM-H2: 0.00
Synonyms: KM-H2, KMH2
T84: 0.00
Synonyms: T84
Download SVG
0.00
5.00
10.00
15.00
20.00
25.00
30.00
35.00
40.00
LS-411N
LS-411N
Geo
Geo
RERF-LC-Sq1
RERF-LC-Sq1
MN-60
MN-60
H2591
H2591
NCI-SNU-1
NCI-SNU-1
MDA-MB-453
MDA-MB-453
NCI-H508
NCI-H508
NCI-H727
NCI-H727
CADO-ES1
CADO-ES1
KNS-81-FD
KNS-81-FD
NCI-H1648
NCI-H1648
SW403
SW403
SLVL
SLVL
NCI-H226
NCI-H226
L-428
L-428
KYSE-510
KYSE-510
LN-405
LN-405
NCI-H2110
NCI-H2110
EW-13
EW-13
NB12
NB12
ETK-1
ETK-1
EHEB
EHEB
KARPAS-299
KARPAS-299
HCC1143
HCC1143
SUP-T1
SUP-T1
NCI-H2347
NCI-H2347
NCI-H1304
NCI-H1304
CCK-81
CCK-81
JHH-2
JHH-2
SKM-1
SKM-1
697
697
YT
YT
NCI-H1703
NCI-H1703
SUP-M2
SUP-M2
ES7
ES7
CRO-AP2
CRO-AP2
RS4;11
RS4;11
RCH-ACV
RCH-ACV
TOV-21G
TOV-21G
YH-13
YH-13
CHP-212
CHP-212
CCRF-CEM
CCRF-CEM
BV-173
BV-173
OCI-LY-7
OCI-LY-7
TUR
TUR
KARPAS-45
KARPAS-45
Hs-633T
Hs-633T
NKM-1
NKM-1
NB14
NB14
NALM-6
NALM-6
JeKo-1
JeKo-1
BE-13
BE-13
HUTU-80
HUTU-80
CGTH-W-1
CGTH-W-1
MOLM-13
MOLM-13
MONO-MAC-6
MONO-MAC-6
ATN-1
ATN-1
ALL-PO
ALL-PO
EoL-1-cell
EoL-1-cell
LS-411N
Geo
RERF-LC-Sq1
MN-60
H2591
NCI-SNU-1
MDA-MB-453
NCI-H508
NCI-H727
CADO-ES1
KNS-81-FD
NCI-H1648
SW403
SLVL
NCI-H226
L-428
KYSE-510
LN-405
NCI-H2110
EW-13
NB12
ETK-1
EHEB
KARPAS-299
HCC1143
SUP-T1
NCI-H2347
NCI-H1304
CCK-81
JHH-2
SKM-1
697
YT
NCI-H1703
SUP-M2
ES7
CRO-AP2
RS4;11
RCH-ACV
TOV-21G
YH-13
CHP-212
CCRF-CEM
BV-173
OCI-LY-7
TUR
KARPAS-45
Hs-633T
NKM-1
NB14
NALM-6
JeKo-1
BE-13
HUTU-80
CGTH-W-1
MOLM-13
MONO-MAC-6
ATN-1
ALL-PO
EoL-1-cell
LS-411N: 39.93 (log10 µM)
Synonyms: LS-411N, LS411N
Geo: 15.90 (log10 µM)
Synonyms: Geo
RERF-LC-Sq1: 6.00 (log10 µM)
Synonyms: RERF-LC-Sq1
MN-60: 5.86 (log10 µM)
Synonyms: MN-60
H2591: 5.06 (log10 µM)
Synonyms: H2591
NCI-SNU-1: 4.87 (log10 µM)
Synonyms: NCI-SNU-1, SNU-1
MDA-MB-453: 4.31 (log10 µM)
Synonyms: MDA-MB-453, MDAMB453, mdamb453
NCI-H508: 4.29 (log10 µM)
Synonyms: NCI-H508, NCIH508
NCI-H727: 4.27 (log10 µM)
Synonyms: NCI-H727, NCIH727
CADO-ES1: 3.63 (log10 µM)
Synonyms: CADO-ES1, CADOES1
KNS-81-FD: 2.99 (log10 µM)
Synonyms: KNS-81-FD, KNS-81
NCI-H1648: 2.80 (log10 µM)
Synonyms: NCI-H1648
SW403: 2.67 (log10 µM)
Synonyms: SW403, SW 403
SLVL: 2.60 (log10 µM)
Synonyms: SLVL
NCI-H226: 2.33 (log10 µM)
Synonyms: NCI-H226, NCIH226
L-428: 2.13 (log10 µM)
Synonyms: L-428, L428
KYSE-510: 2.09 (log10 µM)
Synonyms: KYSE-510, KYSE510
LN-405: 1.89 (log10 µM)
Synonyms: LN-405
NCI-H2110: 1.80 (log10 µM)
Synonyms: NCI-H2110, NCIH2110
EW-13: 1.63 (log10 µM)
Synonyms: EW-13
NB12: 1.59 (log10 µM)
Synonyms: NB12
ETK-1: 1.59 (log10 µM)
Synonyms: ETK-1
EHEB: 1.58 (log10 µM)
Synonyms: EHEB
KARPAS-299: 1.51 (log10 µM)
Synonyms: KARPAS-299, KARPAS299
HCC1143: 1.50 (log10 µM)
Synonyms: HCC1143, hcc1143
SUP-T1: 1.42 (log10 µM)
Synonyms: SUP-T1, SUPT1
NCI-H2347: 1.39 (log10 µM)
Synonyms: NCI-H2347
NCI-H1304: 1.37 (log10 µM)
Synonyms: NCI-H1304
CCK-81: 1.36 (log10 µM)
Synonyms: CCK-81, CCK81
JHH-2: 1.35 (log10 µM)
Synonyms: JHH-2, JHH2
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
SKM-1: -0.09 (log10 µM)
Synonyms: SKM-1, SKM1
697: -0.10 (log10 µM)
Synonyms: 697
YT: -0.10 (log10 µM)
Synonyms: YT
NCI-H1703: -0.11 (log10 µM)
Synonyms: NCI-H1703, NCIH1703
SUP-M2: -0.11 (log10 µM)
Synonyms: SUP-M2, SUPM2
ES7: -0.12 (log10 µM)
Synonyms: ES7
CRO-AP2: -0.16 (log10 µM)
Synonyms: CRO-AP2
RS4;11: -0.18 (log10 µM)
Synonyms: RS4;11, RS4_11, RS4-11, RS411
RCH-ACV: -0.20 (log10 µM)
Synonyms: RCH-ACV, RCHACV
TOV-21G: -0.20 (log10 µM)
Synonyms: TOV-21G, TOV21G
YH-13: -0.20 (log10 µM)
Synonyms: YH-13, YH13
CHP-212: -0.21 (log10 µM)
Synonyms: CHP-212, CHP212
CCRF-CEM: -0.23 (log10 µM)
Synonyms: CCRF-CEM, CCRFCEM
BV-173: -0.24 (log10 µM)
Synonyms: BV-173, BV173
OCI-LY-7: -0.24 (log10 µM)
Synonyms: OCI-LY-7, OCI-LY7
TUR: -0.27 (log10 µM)
Synonyms: TUR
KARPAS-45: -0.27 (log10 µM)
Synonyms: KARPAS-45
Hs-633T: -0.27 (log10 µM)
Synonyms: Hs-633T, Hs633T
NKM-1: -0.28 (log10 µM)
Synonyms: NKM-1
NB14: -0.29 (log10 µM)
Synonyms: NB14
NALM-6: -0.31 (log10 µM)
Synonyms: NALM-6, NALM6
JeKo-1: -0.32 (log10 µM)
Synonyms: JeKo-1, JEKO-1, JEKO1
BE-13: -0.34 (log10 µM)
Synonyms: BE-13
HUTU-80: -0.39 (log10 µM)
Synonyms: HUTU-80, HuTu 80, HuTu_80
CGTH-W-1: -0.49 (log10 µM)
Synonyms: CGTH-W-1, CGTHW1
MOLM-13: -0.80 (log10 µM)
Synonyms: MOLM-13, MOLM13
MONO-MAC-6: -0.84 (log10 µM)
Synonyms: MONO-MAC-6, MONOMAC6
ATN-1: -0.87 (log10 µM)
Synonyms: ATN-1
ALL-PO: -0.96 (log10 µM)
Synonyms: ALL-PO
EoL-1-cell: -1.27 (log10 µM)
Synonyms: EoL-1-cell, EOL-1, EOL1
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
BX-795: AAC
AAC
Tissues
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
0.80
adrenal_gland
adrenal_gland
neuroblastoma
neuroblastoma
breast
breast
prostate
prostate
pleura
pleura
large_intestine
large_intestine
endometrium
endometrium
unknown
unknown
skin
skin
cervix
cervix
pancreas
pancreas
urinary_tract
urinary_tract
salivary_gland
salivary_gland
kidney
kidney
stomach
stomach
lung
lung
placenta
placenta
ovary
ovary
biliary_tract
biliary_tract
vulva
vulva
oesophagus
oesophagus
upper_aerodigestive_tract
upper_aerodigestive_tract
liver
liver
oral_cavity
oral_cavity
thyroid
thyroid
central_nervous_system
central_nervous_system
bone
bone
autonomic_ganglia
autonomic_ganglia
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
other
other
testis
testis
soft_tissue
soft_tissue
head_and_neck
head_and_neck
misc
misc
small_intestine
small_intestine
-1.00
-0.50
0.00
0.50
1.00
1.50
small_intestine
small_intestine
misc
misc
neuroblastoma
neuroblastoma
autonomic_ganglia
autonomic_ganglia
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
other
other
thyroid
thyroid
head_and_neck
head_and_neck
upper_aerodigestive_tract
upper_aerodigestive_tract
bone
bone
ovary
ovary
stomach
stomach
soft_tissue
soft_tissue
vulva
vulva
central_nervous_system
central_nervous_system
urinary_tract
urinary_tract
placenta
placenta
testis
testis
prostate
prostate
kidney
kidney
lung
lung
oesophagus
oesophagus
liver
liver
pleura
pleura
unknown
unknown
salivary_gland
salivary_gland
breast
breast
oral_cavity
oral_cavity
skin
skin
endometrium
endometrium
pancreas
pancreas
cervix
cervix
adrenal_gland
adrenal_gland
large_intestine
large_intestine
biliary_tract
biliary_tract
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to BX-795
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
LSMEM1
GDSC1000
pan-cancer
AAC
-0.086
0.01
mRNA
COQ9
GDSC1000
pan-cancer
AAC
-0.088
0.01
mRNA
OR5V1
GDSC1000
pan-cancer
AAC
-0.086
0.01
mRNA
ADRM1
GDSC1000
pan-cancer
AAC
-0.088
0.01
mRNA
RBL1
GDSC1000
pan-cancer
AAC
0.096
0.01
mRNA
RNF220
GDSC1000
pan-cancer
AAC
0.091
0.01
mRNA
LRRC41
GDSC1000
pan-cancer
AAC
0.09
0.01
mRNA
TCEAL1
GDSC1000
pan-cancer
AAC
-0.1
0.01
mRNA
SCUBE2
GDSC1000
pan-cancer
AAC
-0.092
0.01
mRNA
ICAM3
GDSC1000
pan-cancer
AAC
-0.11
0.01
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