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GDC-0449

Synonyms

SourcesNames Used
GDSC1000GDC0449
FIMMVismodegib
PharmacoGx GDC-0449

External IDs

DatabaseIdentifier
Smiles: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey: BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem: 24776445

FDA Approval Status

Approved
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Top molecular features associated with response to GDC-0449


Feature TypeStandardized
Nominal ANOVA
mRNA TMEM243 FIMM pan-cancer AAC -0.31 0.06
mRNA C6orf141 GDSC1000 pan-cancer AAC 0.071 0.06
mRNA SNRK GDSC1000 pan-cancer AAC 0.078 0.06
mRNA NLK FIMM pan-cancer AAC 0.33 0.06
mRNA FCN1 GDSC1000 pan-cancer AAC 0.066 0.06
mRNA KDM2A GDSC1000 pan-cancer AAC -0.074 0.06
mRNA LEF1 GDSC1000 pan-cancer AAC -0.082 0.06
mRNA NCOA3 FIMM pan-cancer AAC 0.33 0.06
mRNA CNOT4 FIMM pan-cancer AAC 0.35 0.06
mRNA SEMA5A GDSC1000 pan-cancer AAC -0.075 0.06
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