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GDC-0449

GDC-0449

Synonyms

Sources	Names Used
GDSC1000	GDC0449
FIMM	Vismodegib
PharmacoGx	GDC-0449

External IDs

Database	Identifier
Smiles:	CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey:	BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem:	24776445

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to GDC-0449

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	PTPN23	GDSC1000	pan-cancer	AAC	-0.069	0.06
mRNA	POLR2J	GDSC1000	pan-cancer	AAC	-0.067	0.06
mRNA	LCP2	GDSC1000	pan-cancer	AAC	0.093	0.06
mRNA	HIST1H1E	GDSC1000	pan-cancer	AAC	-0.069	0.06
mRNA	C14orf2	FIMM	pan-cancer	AAC	0.35	0.06
mRNA	USP33	GDSC1000	pan-cancer	AAC	0.068	0.06
mRNA	CREG2	GDSC1000	pan-cancer	AAC	0.074	0.06
mRNA	CNOT10	GDSC1000	pan-cancer	AAC	0.08	0.06
mRNA	FAM163A	GDSC1000	pan-cancer	AAC	-0.088	0.06
mRNA	C1D	GDSC1000	pan-cancer	AAC	0.07	0.06

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