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GDC-0449

GDC-0449

Synonyms

Sources	Names Used
GDSC1000	GDC0449
FIMM	Vismodegib
PharmacoGx	GDC-0449

External IDs

Database	Identifier
Smiles:	CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey:	BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem:	24776445

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to GDC-0449

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ZNF85	FIMM	pan-cancer	AAC	0.45	0.02
mRNA	ZNF880	GDSC1000	pan-cancer	AAC	-0.084	0.03
mRNA	ZNF99	GDSC1000	pan-cancer	AAC	-0.091	0.01
mRNA	ZNHIT6	GDSC1000	pan-cancer	AAC	0.086	0.02
mRNA	ZRANB3	GDSC1000	pan-cancer	AAC	0.11	0.002
mRNA	ZSCAN16	GDSC1000	pan-cancer	AAC	-0.078	0.05
mRNA	ZSCAN29	GDSC1000	pan-cancer	AAC	0.083	0.04
mRNA	ZSCAN32	GDSC1000	pan-cancer	AAC	0.12	0.005
mRNA	ZSWIM7	GDSC1000	pan-cancer	AAC	0.068	0.05
mRNA	ZZZ3	GDSC1000	pan-cancer	AAC	0.093	0.009

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