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GDC-0449

Synonyms

SourcesNames Used
GDSC1000GDC0449
FIMMVismodegib
PharmacoGx GDC-0449

External IDs

DatabaseIdentifier
Smiles: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey: BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem: 24776445

FDA Approval Status

Approved
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Top molecular features associated with response to GDC-0449


Feature TypeStandardized
Nominal ANOVA
mRNA ELOVL3 GDSC1000 pan-cancer AAC 0.14 7e-05
mRNA TARS GDSC1000 pan-cancer AAC 0.14 8e-05
mRNA PGAP2 GDSC1000 pan-cancer AAC -0.15 0.0001
mRNA SMC6 GDSC1000 pan-cancer AAC 0.14 0.0001
mRNA GCGR GDSC1000 pan-cancer AAC -0.14 0.0001
mRNA ARHGDIA GDSC1000 pan-cancer AAC -0.14 0.0001
mRNA NDUFA2 GDSC1000 pan-cancer AAC -0.14 0.0001
mRNA FAM208A GDSC1000 pan-cancer AAC 0.14 0.0002
mRNA FAM193A GDSC1000 pan-cancer AAC -0.14 0.0002
mRNA SGSH GDSC1000 pan-cancer AAC -0.13 0.0002
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