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GDC-0449

GDC-0449

Synonyms

Sources	Names Used
GDSC1000	GDC0449
FIMM	Vismodegib
PharmacoGx	GDC-0449

External IDs

Database	Identifier
Smiles:	CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey:	BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem:	24776445

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to GDC-0449

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ZNF735	GDSC1000	pan-cancer	AAC	-0.075	0.04
mRNA	ZNF766	GDSC1000	pan-cancer	AAC	0.1	0.006
mRNA	ZNF77	GDSC1000	pan-cancer	AAC	0.069	0.06
mRNA	ZNF770	GDSC1000	pan-cancer	AAC	0.076	0.04
mRNA	ZNF774	GDSC1000	pan-cancer	AAC	0.09	0.01
mRNA	ZNF812P	GDSC1000	pan-cancer	AAC	0.11	0.001
mRNA	ZNF821	GDSC1000	pan-cancer	AAC	-0.071	0.05
mRNA	ZNF827	GDSC1000	pan-cancer	AAC	-0.078	0.03
mRNA	ZNF835	GDSC1000	pan-cancer	AAC	-0.099	0.005
mRNA	ZNF845	GDSC1000	pan-cancer	AAC	0.079	0.03

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