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GDC-0449

GDC-0449

Synonyms

Sources	Names Used
GDSC1000	GDC0449
FIMM	Vismodegib
PharmacoGx	GDC-0449

External IDs

Database	Identifier
Smiles:	CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey:	BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem:	24776445

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to GDC-0449

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	TMEM243	FIMM	pan-cancer	AAC	-0.31	0.06
mRNA	C6orf141	GDSC1000	pan-cancer	AAC	0.071	0.06
mRNA	SNRK	GDSC1000	pan-cancer	AAC	0.078	0.06
mRNA	NLK	FIMM	pan-cancer	AAC	0.33	0.06
mRNA	FCN1	GDSC1000	pan-cancer	AAC	0.066	0.06
mRNA	KDM2A	GDSC1000	pan-cancer	AAC	-0.074	0.06
mRNA	LEF1	GDSC1000	pan-cancer	AAC	-0.082	0.06
mRNA	NCOA3	FIMM	pan-cancer	AAC	0.33	0.06
mRNA	CNOT4	FIMM	pan-cancer	AAC	0.35	0.06
mRNA	SEMA5A	GDSC1000	pan-cancer	AAC	-0.075	0.06

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