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GDC-0449

GDC-0449

Synonyms

Sources	Names Used
GDSC1000	GDC0449
FIMM	Vismodegib
PharmacoGx	GDC-0449

External IDs

Database	Identifier
Smiles:	CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey:	BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem:	24776445

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to GDC-0449

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	CHAC2	GDSC1000	pan-cancer	AAC	0.073	0.06
mRNA	RBM33	GDSC1000	pan-cancer	AAC	-0.079	0.06
mRNA	TAF12	GDSC1000	pan-cancer	AAC	0.069	0.06
mRNA	FGB	GDSC1000	pan-cancer	AAC	0.071	0.06
mRNA	RAP1GAP2	FIMM	pan-cancer	AAC	0.33	0.06
mRNA	AP3B2	GDSC1000	pan-cancer	AAC	-0.071	0.06
mRNA	C2CD4B	GDSC1000	pan-cancer	AAC	-0.067	0.06
mRNA	TAF1A	GDSC1000	pan-cancer	AAC	0.068	0.06
mRNA	GBGT1	GDSC1000	pan-cancer	AAC	0.07	0.06
mRNA	FAM218A	GDSC1000	pan-cancer	AAC	-0.07	0.06

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