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GDC-0449

GDC-0449

Synonyms

Sources	Names Used
GDSC1000	GDC0449
FIMM	Vismodegib
PharmacoGx	GDC-0449

External IDs

Database	Identifier
Smiles:	CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey:	BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem:	24776445

FDA Approval Status

Approved

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Top molecular features associated with response to GDC-0449

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	GNAO1	GDSC1000	pan-cancer	AAC	-0.074	0.06
mRNA	RPS19	FIMM	pan-cancer	AAC	0.33	0.06
mRNA	NABP1	GDSC1000	pan-cancer	AAC	0.073	0.06
mRNA	CTSZ	FIMM	pan-cancer	AAC	-0.33	0.06
mRNA	PPP1R7	FIMM	pan-cancer	AAC	-0.37	0.06
mRNA	H3F3A	GDSC1000	pan-cancer	AAC	0.069	0.06
mRNA	PIK3IP1	GDSC1000	pan-cancer	AAC	-0.07	0.06
mRNA	THOC2	FIMM	pan-cancer	AAC	0.37	0.06
mRNA	PIH1D1	GDSC1000	pan-cancer	AAC	0.069	0.06
mRNA	FAM110B	GDSC1000	pan-cancer	AAC	-0.074	0.06

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