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GDC-0449

Synonyms

SourcesNames Used
GDSC1000GDC0449
FIMMVismodegib
PharmacoGx GDC-0449

External IDs

DatabaseIdentifier
Smiles: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey: BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem: 24776445

FDA Approval Status

Approved
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Top molecular features associated with response to GDC-0449


Feature TypeStandardized
Nominal ANOVA
mRNA ARHGAP25 GDSC1000 pan-cancer AAC -0.088 0.05
mRNA TPGS1 GDSC1000 pan-cancer AAC -0.07 0.05
mRNA DTX3 GDSC1000 pan-cancer AAC -0.069 0.05
mRNA MCC FIMM pan-cancer AAC -0.34 0.05
mRNA C16orf54 GDSC1000 pan-cancer AAC 0.09 0.05
mRNA C8orf59 GDSC1000 pan-cancer AAC -0.069 0.05
mRNA LSS GDSC1000 pan-cancer AAC -0.07 0.05
mRNA LRRC7 GDSC1000 pan-cancer AAC 0.068 0.05
mRNA C1orf185 GDSC1000 pan-cancer AAC -0.068 0.05
mRNA TOP1 FIMM pan-cancer AAC 0.34 0.05
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