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GDC-0449

Synonyms

SourcesNames Used
GDSC1000GDC0449
FIMMVismodegib
PharmacoGx GDC-0449

External IDs

DatabaseIdentifier
Smiles: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey: BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem: 24776445

FDA Approval Status

Approved
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Top molecular features associated with response to GDC-0449


Feature TypeStandardized
Nominal ANOVA
mRNA GLMN GDSC1000 pan-cancer AAC 0.074 0.05
mRNA KRTDAP GDSC1000 pan-cancer AAC 0.074 0.05
mRNA GPR183 FIMM pan-cancer AAC -0.42 0.05
mRNA CSTF2T GDSC1000 pan-cancer AAC 0.072 0.05
mRNA PSMB8 FIMM pan-cancer AAC -0.39 0.05
mRNA CASP3 GDSC1000 pan-cancer AAC -0.076 0.05
mRNA AKAP8 FIMM pan-cancer AAC 0.38 0.05
mRNA ZNF212 FIMM pan-cancer AAC 0.33 0.05
mRNA APLN GDSC1000 pan-cancer AAC -0.071 0.05
mRNA GIP FIMM pan-cancer AAC -0.33 0.05
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