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GDC-0449

Synonyms

SourcesNames Used
GDSC1000GDC0449
FIMMVismodegib
PharmacoGx GDC-0449

External IDs

DatabaseIdentifier
Smiles: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey: BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem: 24776445

FDA Approval Status

Approved
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Top molecular features associated with response to GDC-0449


Feature TypeStandardized
Nominal ANOVA
mRNA CLUL1 GDSC1000 pan-cancer AAC 0.075 0.05
mRNA BCL7A FIMM pan-cancer AAC 0.34 0.05
mRNA EIF3D GDSC1000 pan-cancer AAC 0.074 0.05
mRNA TM4SF5 FIMM pan-cancer AAC -0.33 0.05
mRNA NARS GDSC1000 pan-cancer AAC 0.072 0.05
mRNA AVEN FIMM pan-cancer AAC -0.33 0.05
mRNA C6orf136 GDSC1000 pan-cancer AAC -0.073 0.05
mRNA XPR1 GDSC1000 pan-cancer AAC 0.075 0.05
mRNA DCAF12L2 GDSC1000 pan-cancer AAC -0.071 0.05
mRNA SAP130 GDSC1000 pan-cancer AAC -0.069 0.05
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