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GDC-0449

Synonyms

SourcesNames Used
GDSC1000GDC0449
FIMMVismodegib
PharmacoGx GDC-0449

External IDs

DatabaseIdentifier
Smiles: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey: BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem: 24776445

FDA Approval Status

Approved
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Top molecular features associated with response to GDC-0449


Feature TypeStandardized
Nominal ANOVA
mRNA CCNK GDSC1000 pan-cancer AAC -0.077 0.04
mRNA SUPT16H FIMM pan-cancer AAC 0.36 0.04
mRNA OR13D1 GDSC1000 pan-cancer AAC 0.071 0.04
mRNA PIAS4 GDSC1000 pan-cancer AAC -0.075 0.04
mRNA ATP5J GDSC1000 pan-cancer AAC -0.074 0.04
mRNA SOD2 GDSC1000 pan-cancer AAC 0.075 0.04
mRNA ATP6V0E1 GDSC1000 pan-cancer AAC -0.077 0.04
mRNA WIPF3 GDSC1000 pan-cancer AAC -0.072 0.04
mRNA SLC25A6 GDSC1000 pan-cancer AAC -0.073 0.04
mRNA ZNF112 GDSC1000 pan-cancer AAC 0.084 0.04
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