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GDC-0449

GDC-0449

Synonyms

Sources	Names Used
GDSC1000	GDC0449
FIMM	Vismodegib
PharmacoGx	GDC-0449

External IDs

Database	Identifier
Smiles:	CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey:	BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem:	24776445

FDA Approval Status

Approved

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Top molecular features associated with response to GDC-0449

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ZDHHC9	GDSC1000	pan-cancer	AAC	-0.085	0.04
mRNA	LAPTM4B	GDSC1000	pan-cancer	AAC	0.11	0.04
mRNA	HMGCS1	FIMM	pan-cancer	AAC	0.35	0.04
mRNA	STRA13	GDSC1000	pan-cancer	AAC	-0.075	0.04
mRNA	RMND5A	FIMM	pan-cancer	AAC	0.35	0.04
mRNA	TAF1C	FIMM	pan-cancer	AAC	0.35	0.04
mRNA	PPM1H	GDSC1000	pan-cancer	AAC	-0.077	0.04
mRNA	ASF1B	GDSC1000	pan-cancer	AAC	-0.077	0.04
mRNA	LRRN4CL	GDSC1000	pan-cancer	AAC	-0.075	0.04
mRNA	SLC39A13	GDSC1000	pan-cancer	AAC	-0.086	0.04

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