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GDC-0449

GDC-0449

Synonyms

Sources	Names Used
GDSC1000	GDC0449
FIMM	Vismodegib
PharmacoGx	GDC-0449

External IDs

Database	Identifier
Smiles:	CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey:	BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem:	24776445

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to GDC-0449

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ELP5	GDSC1000	pan-cancer	AAC	0.075	0.04
mRNA	PLEKHG4B	GDSC1000	pan-cancer	AAC	-0.071	0.04
mRNA	RPS23	GDSC1000	pan-cancer	AAC	0.08	0.04
mRNA	RNF122	FIMM	pan-cancer	AAC	0.37	0.04
mRNA	ZNF236	FIMM	pan-cancer	AAC	-0.34	0.04
mRNA	REPS1	GDSC1000	pan-cancer	AAC	0.076	0.04
mRNA	BHLHE41	FIMM	pan-cancer	AAC	-0.41	0.04
mRNA	SRP72	FIMM	pan-cancer	AAC	0.39	0.04
mRNA	TMEM105	GDSC1000	pan-cancer	AAC	-0.073	0.04
mRNA	LRRC75A	GDSC1000	pan-cancer	AAC	-0.082	0.04

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