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GDC-0449

Synonyms

SourcesNames Used
GDSC1000GDC0449
FIMMVismodegib
PharmacoGx GDC-0449

External IDs

DatabaseIdentifier
Smiles: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey: BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem: 24776445

FDA Approval Status

Approved
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Top molecular features associated with response to GDC-0449


Feature TypeStandardized
Nominal ANOVA
mRNA CNOT3 GDSC1000 pan-cancer AAC -0.073 0.04
mRNA PHLPP2 GDSC1000 pan-cancer AAC 0.072 0.04
mRNA BRPF3 GDSC1000 pan-cancer AAC -0.075 0.04
mRNA CHUK GDSC1000 pan-cancer AAC 0.073 0.04
mRNA SLC1A3 GDSC1000 pan-cancer AAC 0.076 0.04
mRNA HRH1 FIMM pan-cancer AAC -0.36 0.04
mRNA CTTN GDSC1000 pan-cancer AAC -0.13 0.04
mRNA GUCA2A GDSC1000 pan-cancer AAC 0.079 0.04
mRNA DEFB118 GDSC1000 pan-cancer AAC -0.075 0.04
mRNA GPR176 FIMM pan-cancer AAC -0.41 0.04
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