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GDC-0449

GDC-0449

Synonyms

Sources	Names Used
GDSC1000	GDC0449
FIMM	Vismodegib
PharmacoGx	GDC-0449

External IDs

Database	Identifier
Smiles:	CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey:	BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem:	24776445

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to GDC-0449

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	INA	FIMM	pan-cancer	AAC	0.36	0.04
mRNA	CYP11B1	GDSC1000	pan-cancer	AAC	-0.074	0.04
mRNA	AHSA1	FIMM	pan-cancer	AAC	0.34	0.04
mRNA	HEATR9	GDSC1000	pan-cancer	AAC	-0.072	0.04
mRNA	BPIFB1	GDSC1000	pan-cancer	AAC	-0.075	0.04
mRNA	HOXC12	GDSC1000	pan-cancer	AAC	-0.073	0.04
mRNA	TGS1	FIMM	pan-cancer	AAC	0.43	0.04
mRNA	PRICKLE3	GDSC1000	pan-cancer	AAC	-0.076	0.04
mRNA	LRRC69	GDSC1000	pan-cancer	AAC	0.074	0.04
mRNA	PPP1CB	GDSC1000	pan-cancer	AAC	0.075	0.04

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