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GDC-0449

Synonyms

SourcesNames Used
GDSC1000GDC0449
FIMMVismodegib
PharmacoGx GDC-0449

External IDs

DatabaseIdentifier
Smiles: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey: BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem: 24776445

FDA Approval Status

Approved
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Top molecular features associated with response to GDC-0449


Feature TypeStandardized
Nominal ANOVA
mRNA GUCA2B GDSC1000 pan-cancer AAC 0.21 2e-09
mRNA GPAM GDSC1000 pan-cancer AAC 0.17 6e-06
mRNA UGT2B10 GDSC1000 pan-cancer AAC 0.17 9e-06
mRNA ZNF275 GDSC1000 pan-cancer AAC -0.17 1e-05
mRNA RRP8 GDSC1000 pan-cancer AAC -0.17 2e-05
mRNA ASPA GDSC1000 pan-cancer AAC 0.16 2e-05
mRNA PNPT1 GDSC1000 pan-cancer AAC 0.15 2e-05
mRNA CBLN4 GDSC1000 pan-cancer AAC 0.14 3e-05
mRNA RAB1B GDSC1000 pan-cancer AAC -0.15 5e-05
mRNA DCP2 GDSC1000 pan-cancer AAC 0.18 6e-05
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