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GDC-0449

GDC-0449

Synonyms

Sources	Names Used
GDSC1000	GDC0449
FIMM	Vismodegib
PharmacoGx	GDC-0449

External IDs

Database	Identifier
Smiles:	CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey:	BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem:	24776445

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to GDC-0449

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ZZZ3	GDSC1000	pan-cancer	AAC	0.093	0.009
mRNA	UAP1L1	GDSC1000	pan-cancer	AAC	-0.098	0.009
mRNA	SH3GL1	GDSC1000	pan-cancer	AAC	-0.099	0.009
mRNA	CADM2	GDSC1000	pan-cancer	AAC	0.094	0.009
mRNA	RSPO1	GDSC1000	pan-cancer	AAC	-0.093	0.009
mRNA	SEPT2	GDSC1000	pan-cancer	AAC	0.097	0.009
mRNA	SERPINB8	GDSC1000	pan-cancer	AAC	0.094	0.009
mRNA	FAM217A	GDSC1000	pan-cancer	AAC	0.091	0.009
mRNA	CBX7	GDSC1000	pan-cancer	AAC	-0.095	0.009
mRNA	SCO1	GDSC1000	pan-cancer	AAC	0.091	0.009

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