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GDC-0449

Synonyms

SourcesNames Used
GDSC1000GDC0449
FIMMVismodegib
PharmacoGx GDC-0449

External IDs

DatabaseIdentifier
Smiles: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey: BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem: 24776445

FDA Approval Status

Approved
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Top molecular features associated with response to GDC-0449


Feature TypeStandardized
Nominal ANOVA
mRNA LRRC40 GDSC1000 pan-cancer AAC 0.11 0.004
mRNA TMEM27 GDSC1000 pan-cancer AAC 0.11 0.004
mRNA ITCH GDSC1000 pan-cancer AAC 0.11 0.004
mRNA IGSF8 GDSC1000 pan-cancer AAC -0.12 0.004
mRNA LRRC8D GDSC1000 pan-cancer AAC 0.1 0.004
mRNA KCNJ8 GDSC1000 pan-cancer AAC 0.12 0.004
mRNA IGSF1 FIMM pan-cancer AAC 0.46 0.004
mRNA MRPS9 GDSC1000 pan-cancer AAC 0.1 0.004
mRNA KARS GDSC1000 pan-cancer AAC 0.1 0.004
mRNA MCF2L GDSC1000 pan-cancer AAC -0.11 0.004
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