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GDC-0449

Synonyms

SourcesNames Used
GDSC1000GDC0449
FIMMVismodegib
PharmacoGx GDC-0449

External IDs

DatabaseIdentifier
Smiles: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey: BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem: 24776445

FDA Approval Status

Approved
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Top molecular features associated with response to GDC-0449


Feature TypeStandardized
Nominal ANOVA
mRNA AAAS GDSC1000 pan-cancer AAC -0.068 0.06
mRNA ATXN7L3 GDSC1000 pan-cancer AAC -0.073 0.06
mRNA OR1G1 GDSC1000 pan-cancer AAC -0.066 0.06
mRNA UTP20 GDSC1000 pan-cancer AAC 0.067 0.06
mRNA NOX4 FIMM pan-cancer AAC -0.33 0.06
mRNA SCAMP3 FIMM pan-cancer AAC -0.34 0.06
mRNA D2HGDH GDSC1000 pan-cancer AAC -0.068 0.06
mRNA HDAC2 GDSC1000 pan-cancer AAC 0.074 0.06
mRNA C16orf90 GDSC1000 pan-cancer AAC -0.07 0.06
mRNA SEMA3B FIMM pan-cancer AAC 0.39 0.06
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