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GDC-0449

GDC-0449

Synonyms

Sources	Names Used
GDSC1000	GDC0449
FIMM	Vismodegib
PharmacoGx	GDC-0449

External IDs

Database	Identifier
Smiles:	CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Inchikey:	BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem:	24776445

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to GDC-0449

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	NOTUM	GDSC1000	pan-cancer	AAC	-0.11	0.002
mRNA	PPP1R21	GDSC1000	pan-cancer	AAC	0.11	0.002
mRNA	MRPL49	GDSC1000	pan-cancer	AAC	-0.11	0.002
mRNA	SLC38A2	GDSC1000	pan-cancer	AAC	0.11	0.002
mRNA	DNAAF2	GDSC1000	pan-cancer	AAC	0.11	0.002
mRNA	SLC35A4	GDSC1000	pan-cancer	AAC	-0.11	0.002
mRNA	VWA3A	GDSC1000	pan-cancer	AAC	-0.11	0.003
mRNA	TOLLIP	GDSC1000	pan-cancer	AAC	-0.11	0.003
mRNA	HMGXB3	GDSC1000	pan-cancer	AAC	-0.11	0.003
mRNA	CTRB2	GDSC1000	pan-cancer	AAC	0.11	0.003

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