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BIBW2992

BIBW2992

Synonyms

Sources	Names Used
GDSC1000, FIMM	Afatinib
GRAY	BIBW2992
CTRPv2	afatinib
PharmacoGx	BIBW2992

External IDs

Database	Identifier
Smiles:	CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
Inchikey:	ULXXDDBFHOBEHA-CWDCEQMOSA-N
Pubchem:	10184653

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to BIBW2992

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ZFYVE28	CTRPv2	pan-cancer	AAC	-0.14	0.0001
mRNA	ZFYVE21	CTRPv2	pan-cancer	AAC	0.14	0.0004
mRNA	ZFP62	CTRPv2	pan-cancer	AAC	0.099	0.009
mRNA	ZFP37	CTRPv2	pan-cancer	AAC	-0.13	0.0008
mRNA	ZFP36L2	CTRPv2	pan-cancer	AAC	0.17	2e-05
mRNA	ZFP3	CTRPv2	pan-cancer	AAC	0.097	0.01
mRNA	ZEB1	CTRPv2	pan-cancer	AAC	-0.17	2e-05
mRNA	ZDHHC23	CTRPv2	pan-cancer	AAC	0.12	0.002
mRNA	ZDHHC21	CTRPv2	pan-cancer	AAC	0.097	0.009
mRNA	ZCCHC4	CTRPv2	pan-cancer	AAC	-0.11	0.002

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