PharmacoDB

Sources

Names Used

Afatinib

BIBW2992

afatinib

PharmacoGx

BIBW2992

Database	Identifier
Smiles:	CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
Inchikey:	ULXXDDBFHOBEHA-CWDCEQMOSA-N
Pubchem:	10184653

Database

Identifier

Smiles:

CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4

Inchikey:

ULXXDDBFHOBEHA-CWDCEQMOSA-N

Pubchem:

Top molecular features associated with response to BIBW2992

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	DNAH2	FIMM	pan-cancer	AAC	-0.36	0.02
mRNA	FAM118A	FIMM	pan-cancer	AAC	0.36	0.02
mRNA	KIAA0368	FIMM	pan-cancer	AAC	-0.36	0.02
mRNA	MVD	FIMM	pan-cancer	AAC	0.37	0.02
mRNA	SMAD6	FIMM	pan-cancer	AAC	0.35	0.02
mRNA	MSTN	FIMM	pan-cancer	AAC	0.36	0.02
mRNA	TEP1	FIMM	pan-cancer	AAC	0.37	0.02
mRNA	ZBTB38	FIMM	pan-cancer	AAC	-0.39	0.02
mRNA	KIAA0100	FIMM	pan-cancer	AAC	0.39	0.02
mRNA	PTCH1	FIMM	pan-cancer	AAC	0.36	0.02