PharmacoDB

Sources

Names Used

Afatinib

BIBW2992

afatinib

PharmacoGx

BIBW2992

Database	Identifier
Smiles:	CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
Inchikey:	ULXXDDBFHOBEHA-CWDCEQMOSA-N
Pubchem:	10184653

Database

Identifier

Smiles:

CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4

Inchikey:

ULXXDDBFHOBEHA-CWDCEQMOSA-N

Pubchem:

Top molecular features associated with response to BIBW2992

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	DLG3	FIMM	pan-cancer	AAC	0.54	0.004
mRNA	NR2F1	FIMM	pan-cancer	AAC	0.56	0.0005
mRNA	ZNF107	FIMM	pan-cancer	AAC	0.56	0.007
mRNA	CDH5	FIMM	pan-cancer	AAC	0.57	3e-05
mRNA	CLDN16	FIMM	pan-cancer	AAC	0.57	0.002
mRNA	LHX1	FIMM	pan-cancer	AAC	0.58	0.0001
mRNA	CUBN	FIMM	pan-cancer	AAC	0.59	3e-05
mRNA	KCNJ13	FIMM	pan-cancer	AAC	0.59	2e-05
mRNA	REST	FIMM	pan-cancer	AAC	0.59	5e-05
mRNA	CARD8	FIMM	pan-cancer	AAC	0.61	0.01