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AMG-706

AMG-706

Synonyms

Sources	Names Used
GDSC1000	AMG-706
FIMM	Motesanib
PharmacoGx	AMG-706

External IDs

Database	Identifier
Smiles:	CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
Inchikey:	RAHBGWKEPAQNFF-UHFFFAOYSA-N
Pubchem:	11667893

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to AMG-706

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ACVR1B	GDSC1000	pan-cancer	AAC	-0.092	0.01
mRNA	ACVR2A	GDSC1000	pan-cancer	AAC	-0.095	0.02
mRNA	ACYP1	GDSC1000	pan-cancer	AAC	-0.14	0.0001
mRNA	ADAM18	GDSC1000	pan-cancer	AAC	0.084	0.01
mRNA	ADAM2	FIMM	pan-cancer	AAC	0.36	0.03
mRNA	ADAM9	GDSC1000	pan-cancer	AAC	0.15	0.002
mRNA	ADAMTS3	FIMM	pan-cancer	AAC	0.48	0.002
mRNA	ADAMTSL5	GDSC1000	pan-cancer	AAC	0.081	0.02
mRNA	ADCY7	FIMM	pan-cancer	AAC	-0.49	0.01
mRNA	ADGRA2	GDSC1000	pan-cancer	AAC	0.13	0.001

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